Structure of the homodimeric androgen receptor ligand-binding domain

The androgen receptor is crucial for the development and physiology of reproductive organs. Here the authors present the structure of the androgen receptor ligand-binding domain bound to dihydrotestosterone, identifying a homodimerization interface that is crucial for receptor activityin vivo.

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Autores principales:	Marta Nadal, Stefan Prekovic, Nerea Gallastegui, Christine Helsen, Montserrat Abella, Karolina Zielinska, Marina Gay, Marta Vilaseca, Marta Taulès, Adriaan B. Houtsmuller, Martin E. van Royen, Frank Claessens, Pablo Fuentes-Prior, Eva Estébanez-Perpiñá
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e16dab5dd1bd4ba28ae91fea89b288b4
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spelling	oai:doaj.org-article:e16dab5dd1bd4ba28ae91fea89b288b42021-12-02T14:42:00ZStructure of the homodimeric androgen receptor ligand-binding domain10.1038/ncomms143882041-1723https://doaj.org/article/e16dab5dd1bd4ba28ae91fea89b288b42017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14388https://doaj.org/toc/2041-1723The androgen receptor is crucial for the development and physiology of reproductive organs. Here the authors present the structure of the androgen receptor ligand-binding domain bound to dihydrotestosterone, identifying a homodimerization interface that is crucial for receptor activityin vivo.Marta NadalStefan PrekovicNerea GallasteguiChristine HelsenMontserrat AbellaKarolina ZielinskaMarina GayMarta VilasecaMarta TaulèsAdriaan B. HoutsmullerMartin E. van RoyenFrank ClaessensPablo Fuentes-PriorEva Estébanez-PerpiñáNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marta Nadal Stefan Prekovic Nerea Gallastegui Christine Helsen Montserrat Abella Karolina Zielinska Marina Gay Marta Vilaseca Marta Taulès Adriaan B. Houtsmuller Martin E. van Royen Frank Claessens Pablo Fuentes-Prior Eva Estébanez-Perpiñá Structure of the homodimeric androgen receptor ligand-binding domain
description	The androgen receptor is crucial for the development and physiology of reproductive organs. Here the authors present the structure of the androgen receptor ligand-binding domain bound to dihydrotestosterone, identifying a homodimerization interface that is crucial for receptor activityin vivo.
format	article
author	Marta Nadal Stefan Prekovic Nerea Gallastegui Christine Helsen Montserrat Abella Karolina Zielinska Marina Gay Marta Vilaseca Marta Taulès Adriaan B. Houtsmuller Martin E. van Royen Frank Claessens Pablo Fuentes-Prior Eva Estébanez-Perpiñá
author_facet	Marta Nadal Stefan Prekovic Nerea Gallastegui Christine Helsen Montserrat Abella Karolina Zielinska Marina Gay Marta Vilaseca Marta Taulès Adriaan B. Houtsmuller Martin E. van Royen Frank Claessens Pablo Fuentes-Prior Eva Estébanez-Perpiñá
author_sort	Marta Nadal
title	Structure of the homodimeric androgen receptor ligand-binding domain
title_short	Structure of the homodimeric androgen receptor ligand-binding domain
title_full	Structure of the homodimeric androgen receptor ligand-binding domain
title_fullStr	Structure of the homodimeric androgen receptor ligand-binding domain
title_full_unstemmed	Structure of the homodimeric androgen receptor ligand-binding domain
title_sort	structure of the homodimeric androgen receptor ligand-binding domain
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e16dab5dd1bd4ba28ae91fea89b288b4
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Structure of the homodimeric androgen receptor ligand-binding domain

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