Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.

<h4>Background</h4>Areas that are endemic for malaria are also highly endemic for hepatitis B virus (HBV) infection. Nevertheless, it is unknown whether HBV infection modifies the clinical presentation of malaria. This study aimed to address this question.<h4>Methodology and findin...

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Autores principales:	Bruno B Andrade, Cristiane J N Santos, Luís M Camargo, Sebastião M Souza-Neto, Antonio Reis-Filho, Jorge Clarêncio, Vitor R R Mendonça, Nívea F Luz, Erney P Camargo, Aldina Barral, Antônio A M Silva, Manoel Barral-Netto
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e16eae100ff349148b74152ee819677a
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spelling	oai:doaj.org-article:e16eae100ff349148b74152ee819677a2021-11-18T06:53:44ZHepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.1932-620310.1371/journal.pone.0019841https://doaj.org/article/e16eae100ff349148b74152ee819677a2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21625634/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Areas that are endemic for malaria are also highly endemic for hepatitis B virus (HBV) infection. Nevertheless, it is unknown whether HBV infection modifies the clinical presentation of malaria. This study aimed to address this question.<h4>Methodology and findings</h4>An observational study of 636 individuals was performed in Rondônia, western Amazon, Brazil between 2006 and 2007. Active and passive case detections identified Plasmodium infection by field microscopy and nested Polymerase Chain Reaction (PCR). HBV infections were identified by serology and confirmed by real-time PCR. Epidemiological information and plasma cytokine profiles were studied. The data were analyzed using adjusted multinomial logistic regression. Plasmodium-infected individuals with active HBV infection were more likely to be asymptomatic (OR: 120.13, P<0.0001), present with lower levels of parasitemia and demonstrate a decreased inflammatory cytokine profile. Nevertheless, co-infected individuals presented higher HBV viremia. Plasmodium parasitemia inversely correlated with plasma HBV DNA levels (r = -0.6; P = 0.0003).<h4>Conclusion</h4>HBV infection diminishes the intensity of malaria infection in individuals from this endemic area. This effect seems related to cytokine balance and control of inflammatory responses. These findings add important insights to the understanding of the factors affecting the clinical outcomes of malaria in endemic regions.Bruno B AndradeCristiane J N SantosLuís M CamargoSebastião M Souza-NetoAntonio Reis-FilhoJorge ClarêncioVitor R R MendonçaNívea F LuzErney P CamargoAldina BarralAntônio A M SilvaManoel Barral-NettoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e19841 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bruno B Andrade Cristiane J N Santos Luís M Camargo Sebastião M Souza-Neto Antonio Reis-Filho Jorge Clarêncio Vitor R R Mendonça Nívea F Luz Erney P Camargo Aldina Barral Antônio A M Silva Manoel Barral-Netto Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
description	<h4>Background</h4>Areas that are endemic for malaria are also highly endemic for hepatitis B virus (HBV) infection. Nevertheless, it is unknown whether HBV infection modifies the clinical presentation of malaria. This study aimed to address this question.<h4>Methodology and findings</h4>An observational study of 636 individuals was performed in Rondônia, western Amazon, Brazil between 2006 and 2007. Active and passive case detections identified Plasmodium infection by field microscopy and nested Polymerase Chain Reaction (PCR). HBV infections were identified by serology and confirmed by real-time PCR. Epidemiological information and plasma cytokine profiles were studied. The data were analyzed using adjusted multinomial logistic regression. Plasmodium-infected individuals with active HBV infection were more likely to be asymptomatic (OR: 120.13, P<0.0001), present with lower levels of parasitemia and demonstrate a decreased inflammatory cytokine profile. Nevertheless, co-infected individuals presented higher HBV viremia. Plasmodium parasitemia inversely correlated with plasma HBV DNA levels (r = -0.6; P = 0.0003).<h4>Conclusion</h4>HBV infection diminishes the intensity of malaria infection in individuals from this endemic area. This effect seems related to cytokine balance and control of inflammatory responses. These findings add important insights to the understanding of the factors affecting the clinical outcomes of malaria in endemic regions.
format	article
author	Bruno B Andrade Cristiane J N Santos Luís M Camargo Sebastião M Souza-Neto Antonio Reis-Filho Jorge Clarêncio Vitor R R Mendonça Nívea F Luz Erney P Camargo Aldina Barral Antônio A M Silva Manoel Barral-Netto
author_facet	Bruno B Andrade Cristiane J N Santos Luís M Camargo Sebastião M Souza-Neto Antonio Reis-Filho Jorge Clarêncio Vitor R R Mendonça Nívea F Luz Erney P Camargo Aldina Barral Antônio A M Silva Manoel Barral-Netto
author_sort	Bruno B Andrade
title	Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
title_short	Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
title_full	Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
title_fullStr	Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
title_full_unstemmed	Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
title_sort	hepatitis b infection is associated with asymptomatic malaria in the brazilian amazon.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/e16eae100ff349148b74152ee819677a
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Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.

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