IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis.
Both interleukin (IL)-33 and IL-25 induce Th2 cytokine production by various cell types, suggesting that they contribute to development of allergic disorders. However, the precise roles of IL-33 and IL-25 in house dust mite (HDM)-induced allergic rhinitis (AR) remain unclear. Both IL-33 and IL-25 we...
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oai:doaj.org-article:e170c11784454e06b17cb6087b4db2cd2021-11-18T08:49:24ZIL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis.1932-620310.1371/journal.pone.0078099https://doaj.org/article/e170c11784454e06b17cb6087b4db2cd2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24205109/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Both interleukin (IL)-33 and IL-25 induce Th2 cytokine production by various cell types, suggesting that they contribute to development of allergic disorders. However, the precise roles of IL-33 and IL-25 in house dust mite (HDM)-induced allergic rhinitis (AR) remain unclear. Both IL-33 and IL-25 were produced mainly by nasal epithelial cells during HDM-induced AR. Eosinophil and goblet cell counts in the nose and IL-5 levels in lymph node cell culture supernatants were significantly decreased in IL-33-deficient, but not IL-25-deficient, mice compared with wild-type mice during HDM-induced AR, but the serum IgE and IgG1 levels did not differ. On the other hand, HDM-induced AR developed similarly in wild-type mice transferred with either IL-33-deficient BM cells or wild-type BM cells. IL-33, but not IL-25, produced by nasal epithelial cells was crucial for the development of murine HDM-induced AR. These observations suggest that IL-33 neutralization may be a potential approach for treatment of HDM-induced AR in humans.Wakako NakanishiSachiko YamaguchiAkira MatsudaMaho SuzukawaAkiko ShibuiAya NambuKenji KondoHajime SutoHirohisa SaitoKenji MatsumotoTatuya YamasobaSusumu NakaePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e78099 (2013) |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Wakako Nakanishi Sachiko Yamaguchi Akira Matsuda Maho Suzukawa Akiko Shibui Aya Nambu Kenji Kondo Hajime Suto Hirohisa Saito Kenji Matsumoto Tatuya Yamasoba Susumu Nakae IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. |
| description |
Both interleukin (IL)-33 and IL-25 induce Th2 cytokine production by various cell types, suggesting that they contribute to development of allergic disorders. However, the precise roles of IL-33 and IL-25 in house dust mite (HDM)-induced allergic rhinitis (AR) remain unclear. Both IL-33 and IL-25 were produced mainly by nasal epithelial cells during HDM-induced AR. Eosinophil and goblet cell counts in the nose and IL-5 levels in lymph node cell culture supernatants were significantly decreased in IL-33-deficient, but not IL-25-deficient, mice compared with wild-type mice during HDM-induced AR, but the serum IgE and IgG1 levels did not differ. On the other hand, HDM-induced AR developed similarly in wild-type mice transferred with either IL-33-deficient BM cells or wild-type BM cells. IL-33, but not IL-25, produced by nasal epithelial cells was crucial for the development of murine HDM-induced AR. These observations suggest that IL-33 neutralization may be a potential approach for treatment of HDM-induced AR in humans. |
| format |
article |
| author |
Wakako Nakanishi Sachiko Yamaguchi Akira Matsuda Maho Suzukawa Akiko Shibui Aya Nambu Kenji Kondo Hajime Suto Hirohisa Saito Kenji Matsumoto Tatuya Yamasoba Susumu Nakae |
| author_facet |
Wakako Nakanishi Sachiko Yamaguchi Akira Matsuda Maho Suzukawa Akiko Shibui Aya Nambu Kenji Kondo Hajime Suto Hirohisa Saito Kenji Matsumoto Tatuya Yamasoba Susumu Nakae |
| author_sort |
Wakako Nakanishi |
| title |
IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. |
| title_short |
IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. |
| title_full |
IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. |
| title_fullStr |
IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. |
| title_full_unstemmed |
IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. |
| title_sort |
il-33, but not il-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/e170c11784454e06b17cb6087b4db2cd |
| work_keys_str_mv |
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