A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis

Extracellular vesicles (EVs) contain VEGF and can contribute to tumour angiogenesis, although the mechanism remains unclear. Here, the authors find that a form of VEGF (VEGF90K) resistant to Bevacizumab but sensitive to HSP90 inhibitors, associates with EVs through its interaction with Hsp90.

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Autores principales:	Qiyu Feng, Chengliang Zhang, David Lum, Joseph E. Druso, Bryant Blank, Kristin F. Wilson, Alana Welm, Marc A. Antonyak, Richard A. Cerione
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e17371e6af1d4dfba0a044b7db0d7907
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:e17371e6af1d4dfba0a044b7db0d79072021-12-02T14:42:08ZA class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis10.1038/ncomms144502041-1723https://doaj.org/article/e17371e6af1d4dfba0a044b7db0d79072017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14450https://doaj.org/toc/2041-1723Extracellular vesicles (EVs) contain VEGF and can contribute to tumour angiogenesis, although the mechanism remains unclear. Here, the authors find that a form of VEGF (VEGF90K) resistant to Bevacizumab but sensitive to HSP90 inhibitors, associates with EVs through its interaction with Hsp90.Qiyu FengChengliang ZhangDavid LumJoseph E. DrusoBryant BlankKristin F. WilsonAlana WelmMarc A. AntonyakRichard A. CerioneNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiyu Feng Chengliang Zhang David Lum Joseph E. Druso Bryant Blank Kristin F. Wilson Alana Welm Marc A. Antonyak Richard A. Cerione A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis
description	Extracellular vesicles (EVs) contain VEGF and can contribute to tumour angiogenesis, although the mechanism remains unclear. Here, the authors find that a form of VEGF (VEGF90K) resistant to Bevacizumab but sensitive to HSP90 inhibitors, associates with EVs through its interaction with Hsp90.
format	article
author	Qiyu Feng Chengliang Zhang David Lum Joseph E. Druso Bryant Blank Kristin F. Wilson Alana Welm Marc A. Antonyak Richard A. Cerione
author_facet	Qiyu Feng Chengliang Zhang David Lum Joseph E. Druso Bryant Blank Kristin F. Wilson Alana Welm Marc A. Antonyak Richard A. Cerione
author_sort	Qiyu Feng
title	A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis
title_short	A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis
title_full	A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis
title_fullStr	A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis
title_full_unstemmed	A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis
title_sort	class of extracellular vesicles from breast cancer cells activates vegf receptors and tumour angiogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e17371e6af1d4dfba0a044b7db0d7907
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A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis

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