A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis

A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis

Extracellular vesicles (EVs) contain VEGF and can contribute to tumour angiogenesis, although the mechanism remains unclear. Here, the authors find that a form of VEGF (VEGF90K) resistant to Bevacizumab but sensitive to HSP90 inhibitors, associates with EVs through its interaction with Hsp90.

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Detalles Bibliográficos
Autores principales: Qiyu Feng, Chengliang Zhang, David Lum, Joseph E. Druso, Bryant Blank, Kristin F. Wilson, Alana Welm, Marc A. Antonyak, Richard A. Cerione
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/e17371e6af1d4dfba0a044b7db0d7907
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