Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice

Diabetes is associated with the de-differentiation of β-cells into a more progenitor-like cell type. Here, the authors identify Aldh3 as a marker of de-differentiating β-cell in animal models of diabetes, and show Aldh3+cells have impaired insulin secretion and mitochondrial dysfunction.

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Autores principales:	Ja Young Kim-Muller, Jason Fan, Young Jung R. Kim, Seung-Ah Lee, Emi Ishida, William S. Blaner, Domenico Accili
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e17584f62b6c47f0ad9963510af7d64a
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spelling	oai:doaj.org-article:e17584f62b6c47f0ad9963510af7d64a2021-12-02T16:49:41ZAldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice10.1038/ncomms126312041-1723https://doaj.org/article/e17584f62b6c47f0ad9963510af7d64a2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12631https://doaj.org/toc/2041-1723Diabetes is associated with the de-differentiation of β-cells into a more progenitor-like cell type. Here, the authors identify Aldh3 as a marker of de-differentiating β-cell in animal models of diabetes, and show Aldh3+cells have impaired insulin secretion and mitochondrial dysfunction.Ja Young Kim-MullerJason FanYoung Jung R. KimSeung-Ah LeeEmi IshidaWilliam S. BlanerDomenico AcciliNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ja Young Kim-Muller Jason Fan Young Jung R. Kim Seung-Ah Lee Emi Ishida William S. Blaner Domenico Accili Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice
description	Diabetes is associated with the de-differentiation of β-cells into a more progenitor-like cell type. Here, the authors identify Aldh3 as a marker of de-differentiating β-cell in animal models of diabetes, and show Aldh3+cells have impaired insulin secretion and mitochondrial dysfunction.
format	article
author	Ja Young Kim-Muller Jason Fan Young Jung R. Kim Seung-Ah Lee Emi Ishida William S. Blaner Domenico Accili
author_facet	Ja Young Kim-Muller Jason Fan Young Jung R. Kim Seung-Ah Lee Emi Ishida William S. Blaner Domenico Accili
author_sort	Ja Young Kim-Muller
title	Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice
title_short	Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice
title_full	Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice
title_fullStr	Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice
title_full_unstemmed	Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice
title_sort	aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e17584f62b6c47f0ad9963510af7d64a
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Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice

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