Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases

Ursolic acid (UA) is a pentacyclic triterpenoid frequently found in medicinal herbs and plants, having numerous pharmacological effects. UA and its analogs treat multiple diseases, including cancer, diabetic neuropathy, and inflammatory diseases. UA inhibits cancer proliferation, metastasis, angioge...

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Autores principales:	Manzar Alam, Sabeeha Ali, Sarfraz Ahmed, Abdelbaset Mohamed Elasbali, Mohd Adnan, Asimul Islam, Md. Imtaiyaz Hassan, Dharmendra Kumar Yadav
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ursolic acid clinical trials diabetic neuropathy inflammatory diseases inhibitors targeted therapy Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e17bd67e0fb74c92a8e8c2850d80e840
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spelling	oai:doaj.org-article:e17bd67e0fb74c92a8e8c2850d80e8402021-11-25T17:53:55ZTherapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases10.3390/ijms2222121621422-00671661-6596https://doaj.org/article/e17bd67e0fb74c92a8e8c2850d80e8402021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12162https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Ursolic acid (UA) is a pentacyclic triterpenoid frequently found in medicinal herbs and plants, having numerous pharmacological effects. UA and its analogs treat multiple diseases, including cancer, diabetic neuropathy, and inflammatory diseases. UA inhibits cancer proliferation, metastasis, angiogenesis, and induced cell death, scavenging free radicals and triggering numerous anti- and pro-apoptotic proteins. The biochemistry of UA has been examined broadly based on the literature, with alterations frequently having been prepared on positions C-3 (hydroxyl), C12–C13 (double bonds), and C-28 (carboxylic acid), leading to several UA derivatives with increased potency, bioavailability and water solubility. UA could be used as a protective agent to counter neural dysfunction via anti-oxidant and anti-inflammatory effects. It is a potential therapeutic drug implicated in the treatment of cancer and diabetic complications diseases provide novel machinery to the anti-inflammatory properties of UA. The pharmacological efficiency of UA is exhibited by the therapeutic theory of one-drug → several targets → one/multiple diseases. Hence, UA shows promising therapeutic potential for cancer and diabetic neuropathy diseases. This review aims to discuss mechanistic insights into promising beneficial effects of UA. We further explained the pharmacological aspects, clinical trials, and potential limitations of UA for the management of cancer and diabetic neuropathy diseases.Manzar AlamSabeeha AliSarfraz AhmedAbdelbaset Mohamed ElasbaliMohd AdnanAsimul IslamMd. Imtaiyaz HassanDharmendra Kumar YadavMDPI AGarticleursolic acidclinical trialsdiabetic neuropathyinflammatory diseasesinhibitorstargeted therapyBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12162, p 12162 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ursolic acid clinical trials diabetic neuropathy inflammatory diseases inhibitors targeted therapy Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	ursolic acid clinical trials diabetic neuropathy inflammatory diseases inhibitors targeted therapy Biology (General) QH301-705.5 Chemistry QD1-999 Manzar Alam Sabeeha Ali Sarfraz Ahmed Abdelbaset Mohamed Elasbali Mohd Adnan Asimul Islam Md. Imtaiyaz Hassan Dharmendra Kumar Yadav Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases
description	Ursolic acid (UA) is a pentacyclic triterpenoid frequently found in medicinal herbs and plants, having numerous pharmacological effects. UA and its analogs treat multiple diseases, including cancer, diabetic neuropathy, and inflammatory diseases. UA inhibits cancer proliferation, metastasis, angiogenesis, and induced cell death, scavenging free radicals and triggering numerous anti- and pro-apoptotic proteins. The biochemistry of UA has been examined broadly based on the literature, with alterations frequently having been prepared on positions C-3 (hydroxyl), C12–C13 (double bonds), and C-28 (carboxylic acid), leading to several UA derivatives with increased potency, bioavailability and water solubility. UA could be used as a protective agent to counter neural dysfunction via anti-oxidant and anti-inflammatory effects. It is a potential therapeutic drug implicated in the treatment of cancer and diabetic complications diseases provide novel machinery to the anti-inflammatory properties of UA. The pharmacological efficiency of UA is exhibited by the therapeutic theory of one-drug → several targets → one/multiple diseases. Hence, UA shows promising therapeutic potential for cancer and diabetic neuropathy diseases. This review aims to discuss mechanistic insights into promising beneficial effects of UA. We further explained the pharmacological aspects, clinical trials, and potential limitations of UA for the management of cancer and diabetic neuropathy diseases.
format	article
author	Manzar Alam Sabeeha Ali Sarfraz Ahmed Abdelbaset Mohamed Elasbali Mohd Adnan Asimul Islam Md. Imtaiyaz Hassan Dharmendra Kumar Yadav
author_facet	Manzar Alam Sabeeha Ali Sarfraz Ahmed Abdelbaset Mohamed Elasbali Mohd Adnan Asimul Islam Md. Imtaiyaz Hassan Dharmendra Kumar Yadav
author_sort	Manzar Alam
title	Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases
title_short	Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases
title_full	Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases
title_fullStr	Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases
title_full_unstemmed	Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases
title_sort	therapeutic potential of ursolic acid in cancer and diabetic neuropathy diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e17bd67e0fb74c92a8e8c2850d80e840
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Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases

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