Trabeculectomy with double low dose of mitomycin C – two years of follow-up

Trabeculectomy with double low dose of mitomycin C – two years of follow-up

Donato Errico1, Francesca Scrimieri1, Roberta Riccardi1, Romolo Fedeli1, Giancarlo Iarossi21Opthalmology Unit, Glaucoma Service, Azienda Ospedaliera, Cardinale G Panìco, Tricase (Le), Italy; 2Department of Opthalmology, Ospedale Pediatrico Bambino Gesù, Rome, ItalyPurpo...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Errico D, Scrimieri F, Riccardi R, Fedeli R, Iarossi G
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2011
Materias:
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/e17c56fd42814e708732aef39525be2b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:e17c56fd42814e708732aef39525be2b
record_format dspace
spelling oai:doaj.org-article:e17c56fd42814e708732aef39525be2b2021-12-02T04:54:22ZTrabeculectomy with double low dose of mitomycin C – two years of follow-up1177-54671177-5483https://doaj.org/article/e17c56fd42814e708732aef39525be2b2011-12-01T00:00:00Zhttp://www.dovepress.com/trabeculectomy-with-double-low-dose-of-mitomycin-c-ndash-two-years-of--a8773https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Donato Errico1, Francesca Scrimieri1, Roberta Riccardi1, Romolo Fedeli1, Giancarlo Iarossi21Opthalmology Unit, Glaucoma Service, Azienda Ospedaliera, Cardinale G Panìco, Tricase (Le), Italy; 2Department of Opthalmology, Ospedale Pediatrico Bambino Gesù, Rome, ItalyPurpose: To evaluate the efficacy and the safety of a surgical technique in which classic trabeculectomy ab externo is performed with a double application of low-dose mitomycin C (MMC) in uncontrolled open-angle glaucoma (OAG) patients.Method: A consecutive series of 43 white patients (43 eyes) with uncontrolled primary OAG underwent trabeculectomy surgery. A double application of MMC (0.1%) was performed: the first under the Tenon's capsule for 3 minutes, and the second below the scleral flap for 1 or 2 minutes, according to the risk factors. Complete success was defined as intraocular pressure (IOP) <14 mmHg without any additional glaucoma surgery or medication. Qualified success was defined as IOP <14 mmHg with additional needling revision.Results: Mean preoperative IOP was 29.9 mmHg (SD 3.8) for all eyes evaluated. At 1 day postoperative, mean IOP was 6.7 mmHg (SD 1.26). At the end of the first 2 weeks postoperative, mean IOP was 8.6 mmHg (SD 1.7), at 12 months mean IOP was 11.3 mmHg (SD 1.4; P < 0.0001) and at 24 months mean IOP was 11.4 mmHg (SD 1.5; P < 0.0001). At 3 months, two eyes (5.4%) underwent needling of the bleb for cystic blebs formation.Conclusion: In this study we presented the results after 2 years of follow-up of OAG undergoing trabeculectomy with dual administration of MMC (0.1 mg/mL). After 24 months, complete success was achieved in 93% of patients and a qualified success in 100% of patients.Keywords: glaucoma, trabeculectomy, mitomycin CErrico DScrimieri FRiccardi RFedeli RIarossi GDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1679-1686 (2011)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Errico D
Scrimieri F
Riccardi R
Fedeli R
Iarossi G
Trabeculectomy with double low dose of mitomycin C – two years of follow-up
description Donato Errico1, Francesca Scrimieri1, Roberta Riccardi1, Romolo Fedeli1, Giancarlo Iarossi21Opthalmology Unit, Glaucoma Service, Azienda Ospedaliera, Cardinale G Panìco, Tricase (Le), Italy; 2Department of Opthalmology, Ospedale Pediatrico Bambino Gesù, Rome, ItalyPurpose: To evaluate the efficacy and the safety of a surgical technique in which classic trabeculectomy ab externo is performed with a double application of low-dose mitomycin C (MMC) in uncontrolled open-angle glaucoma (OAG) patients.Method: A consecutive series of 43 white patients (43 eyes) with uncontrolled primary OAG underwent trabeculectomy surgery. A double application of MMC (0.1%) was performed: the first under the Tenon's capsule for 3 minutes, and the second below the scleral flap for 1 or 2 minutes, according to the risk factors. Complete success was defined as intraocular pressure (IOP) <14 mmHg without any additional glaucoma surgery or medication. Qualified success was defined as IOP <14 mmHg with additional needling revision.Results: Mean preoperative IOP was 29.9 mmHg (SD 3.8) for all eyes evaluated. At 1 day postoperative, mean IOP was 6.7 mmHg (SD 1.26). At the end of the first 2 weeks postoperative, mean IOP was 8.6 mmHg (SD 1.7), at 12 months mean IOP was 11.3 mmHg (SD 1.4; P < 0.0001) and at 24 months mean IOP was 11.4 mmHg (SD 1.5; P < 0.0001). At 3 months, two eyes (5.4%) underwent needling of the bleb for cystic blebs formation.Conclusion: In this study we presented the results after 2 years of follow-up of OAG undergoing trabeculectomy with dual administration of MMC (0.1 mg/mL). After 24 months, complete success was achieved in 93% of patients and a qualified success in 100% of patients.Keywords: glaucoma, trabeculectomy, mitomycin C
format article
author Errico D
Scrimieri F
Riccardi R
Fedeli R
Iarossi G
author_facet Errico D
Scrimieri F
Riccardi R
Fedeli R
Iarossi G
author_sort Errico D
title Trabeculectomy with double low dose of mitomycin C – two years of follow-up
title_short Trabeculectomy with double low dose of mitomycin C – two years of follow-up
title_full Trabeculectomy with double low dose of mitomycin C – two years of follow-up
title_fullStr Trabeculectomy with double low dose of mitomycin C – two years of follow-up
title_full_unstemmed Trabeculectomy with double low dose of mitomycin C – two years of follow-up
title_sort trabeculectomy with double low dose of mitomycin c – two years of follow-up
publisher Dove Medical Press
publishDate 2011
url https://doaj.org/article/e17c56fd42814e708732aef39525be2b
work_keys_str_mv AT erricod trabeculectomywithdoublelowdoseofmitomycincampndashtwoyearsoffollowup
AT scrimierif trabeculectomywithdoublelowdoseofmitomycincampndashtwoyearsoffollowup
AT riccardir trabeculectomywithdoublelowdoseofmitomycincampndashtwoyearsoffollowup
AT fedelir trabeculectomywithdoublelowdoseofmitomycincampndashtwoyearsoffollowup
AT iarossig trabeculectomywithdoublelowdoseofmitomycincampndashtwoyearsoffollowup
_version_ 1718401041493393408

Ejemplares similares