Engineering biosynthesis of the anticancer alkaloid noscapine in yeast

Noscapine is a potential anticancer drug that is traditionally isolated from the opium poppy Papaver somniferum. Here, Li and Smolke reconstitute the noscapine gene cluster in Saccharomyces cerevisiae, to achieve the microbial production of noscapine and related pathway intermediates, and provide ne...

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Autores principales:	Yanran Li, Christina D. Smolke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e17cdfdde5c1453e9d5c1f4fbd7295a0
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spelling	oai:doaj.org-article:e17cdfdde5c1453e9d5c1f4fbd7295a02021-12-02T14:38:36ZEngineering biosynthesis of the anticancer alkaloid noscapine in yeast10.1038/ncomms121372041-1723https://doaj.org/article/e17cdfdde5c1453e9d5c1f4fbd7295a02016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12137https://doaj.org/toc/2041-1723Noscapine is a potential anticancer drug that is traditionally isolated from the opium poppy Papaver somniferum. Here, Li and Smolke reconstitute the noscapine gene cluster in Saccharomyces cerevisiae, to achieve the microbial production of noscapine and related pathway intermediates, and provide new insights into the biosynthesis of noscapine.Yanran LiChristina D. SmolkeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yanran Li Christina D. Smolke Engineering biosynthesis of the anticancer alkaloid noscapine in yeast
description	Noscapine is a potential anticancer drug that is traditionally isolated from the opium poppy Papaver somniferum. Here, Li and Smolke reconstitute the noscapine gene cluster in Saccharomyces cerevisiae, to achieve the microbial production of noscapine and related pathway intermediates, and provide new insights into the biosynthesis of noscapine.
format	article
author	Yanran Li Christina D. Smolke
author_facet	Yanran Li Christina D. Smolke
author_sort	Yanran Li
title	Engineering biosynthesis of the anticancer alkaloid noscapine in yeast
title_short	Engineering biosynthesis of the anticancer alkaloid noscapine in yeast
title_full	Engineering biosynthesis of the anticancer alkaloid noscapine in yeast
title_fullStr	Engineering biosynthesis of the anticancer alkaloid noscapine in yeast
title_full_unstemmed	Engineering biosynthesis of the anticancer alkaloid noscapine in yeast
title_sort	engineering biosynthesis of the anticancer alkaloid noscapine in yeast
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e17cdfdde5c1453e9d5c1f4fbd7295a0
work_keys_str_mv	AT yanranli engineeringbiosynthesisoftheanticanceralkaloidnoscapineinyeast AT christinadsmolke engineeringbiosynthesisoftheanticanceralkaloidnoscapineinyeast
_version_	1718390983264043008

Engineering biosynthesis of the anticancer alkaloid noscapine in yeast

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