Treatment of Lennox-Gastaut syndrome: overview and recent findings

Kenou van RijckevorselReference Centre of Refractory Epilepsy, Cliniques Universitaires St Luc, Universit&eacute; Catholique de Louvain, Brussels, BelgiumAbstract: Lennox-Gastaut syndrome (LGS) is a rare, age-related syndrome, characterized by multiple seizure types, a specific electro-encep...

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Autor principal:	Kenou van Rijckevorsel
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e17d0b53250746c99f5b052278c3f4ad
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spelling	oai:doaj.org-article:e17d0b53250746c99f5b052278c3f4ad2021-12-02T01:13:56ZTreatment of Lennox-Gastaut syndrome: overview and recent findings1176-63281178-2021https://doaj.org/article/e17d0b53250746c99f5b052278c3f4ad2008-11-01T00:00:00Zhttp://www.dovepress.com/treatment-of-lennox-gastaut-syndrome-overview-and-recent-findings-a2558https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Kenou van RijckevorselReference Centre of Refractory Epilepsy, Cliniques Universitaires St Luc, Universit&eacute; Catholique de Louvain, Brussels, BelgiumAbstract: Lennox-Gastaut syndrome (LGS) is a rare, age-related syndrome, characterized by multiple seizure types, a specific electro-encephalographic pattern, and mental regression. However, published data on the etiology, evolution, and therapeutic approach of LGS are contradictory, partly because the precise definition of LGS used in the literature varies. In the most recent classification, LGS belongs to the epileptic encephalopathies and is highly refractory to all antiepileptic drugs. Numerous treatments, medical and non-medical, have been proposed and results mostly from open studies or case series have been published. Sometimes, patients with LGS are included in a more global group of patients with refractory epilepsy. Only 6 randomized double-blind controlled trials of medical treatments, which included patients with LGS, have been published. Overall, treatment is rarely effective and the final prognosis remains poor in spite of new therapeutic strategies. Co-morbidities need specific treatment. This paper summarizes the definition, diagnosis and therapeutic approach to LGS, including not only recognized antiepileptic drugs, but also &ldquo;off label&rdquo; medications, immune therapy, diet, surgery and some perspectives for the future.Keywords: Lennox-Gastaut syndrome, treatment, VNS, surgery, epileptic encephalopathies, LGS, refractory Kenou van RijckevorselDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 6, Pp 1001-1019 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kenou van Rijckevorsel Treatment of Lennox-Gastaut syndrome: overview and recent findings
description	Kenou van RijckevorselReference Centre of Refractory Epilepsy, Cliniques Universitaires St Luc, Universit&eacute; Catholique de Louvain, Brussels, BelgiumAbstract: Lennox-Gastaut syndrome (LGS) is a rare, age-related syndrome, characterized by multiple seizure types, a specific electro-encephalographic pattern, and mental regression. However, published data on the etiology, evolution, and therapeutic approach of LGS are contradictory, partly because the precise definition of LGS used in the literature varies. In the most recent classification, LGS belongs to the epileptic encephalopathies and is highly refractory to all antiepileptic drugs. Numerous treatments, medical and non-medical, have been proposed and results mostly from open studies or case series have been published. Sometimes, patients with LGS are included in a more global group of patients with refractory epilepsy. Only 6 randomized double-blind controlled trials of medical treatments, which included patients with LGS, have been published. Overall, treatment is rarely effective and the final prognosis remains poor in spite of new therapeutic strategies. Co-morbidities need specific treatment. This paper summarizes the definition, diagnosis and therapeutic approach to LGS, including not only recognized antiepileptic drugs, but also &ldquo;off label&rdquo; medications, immune therapy, diet, surgery and some perspectives for the future.Keywords: Lennox-Gastaut syndrome, treatment, VNS, surgery, epileptic encephalopathies, LGS, refractory
format	article
author	Kenou van Rijckevorsel
author_facet	Kenou van Rijckevorsel
author_sort	Kenou van Rijckevorsel
title	Treatment of Lennox-Gastaut syndrome: overview and recent findings
title_short	Treatment of Lennox-Gastaut syndrome: overview and recent findings
title_full	Treatment of Lennox-Gastaut syndrome: overview and recent findings
title_fullStr	Treatment of Lennox-Gastaut syndrome: overview and recent findings
title_full_unstemmed	Treatment of Lennox-Gastaut syndrome: overview and recent findings
title_sort	treatment of lennox-gastaut syndrome: overview and recent findings
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/e17d0b53250746c99f5b052278c3f4ad
work_keys_str_mv	AT kenouvanrijckevorsel treatmentoflennoxgastautsyndromeoverviewandrecentfindings
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Treatment of Lennox-Gastaut syndrome: overview and recent findings

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