Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms

Glucocorticoid receptors (GR) are thought to bind DNA as dimers or monomers, to regulate different transcription pathways. Here, the authors perform genome-wide studies on GRs with mutations that impair dimerization and provide evidence that monomeric GRs do not play a significant physiologic role.

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Autores principales:	Thomas A. Johnson, Ville Paakinaho, Sohyoung Kim, Gordon L. Hager, Diego M. Presman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e17e7e034ed64487b45fd4206fa584e1
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spelling	oai:doaj.org-article:e17e7e034ed64487b45fd4206fa584e12021-12-02T14:25:02ZGenome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms10.1038/s41467-021-22234-92041-1723https://doaj.org/article/e17e7e034ed64487b45fd4206fa584e12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22234-9https://doaj.org/toc/2041-1723Glucocorticoid receptors (GR) are thought to bind DNA as dimers or monomers, to regulate different transcription pathways. Here, the authors perform genome-wide studies on GRs with mutations that impair dimerization and provide evidence that monomeric GRs do not play a significant physiologic role.Thomas A. JohnsonVille PaakinahoSohyoung KimGordon L. HagerDiego M. PresmanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas A. Johnson Ville Paakinaho Sohyoung Kim Gordon L. Hager Diego M. Presman Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms
description	Glucocorticoid receptors (GR) are thought to bind DNA as dimers or monomers, to regulate different transcription pathways. Here, the authors perform genome-wide studies on GRs with mutations that impair dimerization and provide evidence that monomeric GRs do not play a significant physiologic role.
format	article
author	Thomas A. Johnson Ville Paakinaho Sohyoung Kim Gordon L. Hager Diego M. Presman
author_facet	Thomas A. Johnson Ville Paakinaho Sohyoung Kim Gordon L. Hager Diego M. Presman
author_sort	Thomas A. Johnson
title	Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms
title_short	Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms
title_full	Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms
title_fullStr	Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms
title_full_unstemmed	Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms
title_sort	genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e17e7e034ed64487b45fd4206fa584e1
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Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms

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