Tissue-specific targeting of DNA nanodevices in a multicellular living organism

Nucleic acid nanodevices present great potential as agents for logic-based therapeutic intervention as well as in basic biology. Often, however, the disease targets that need corrective action are localized in specific organs, and thus realizing the full potential of DNA nanodevices also requires wa...

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Autores principales:	Kasturi Chakraborty, Palapuravan Anees, Sunaina Surana, Simona Martin, Jihad Aburas, Sandrine Moutel, Franck Perez, Sandhya P Koushika, Paschalis Kratsios, Yamuna Krishnan
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	DNA nanotechnology endocytosis lysosomes cell membrane live imaging nematodes Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e17f89fffdfc4f8583ce3191789eed92
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spelling	oai:doaj.org-article:e17f89fffdfc4f8583ce3191789eed922021-11-16T14:22:19ZTissue-specific targeting of DNA nanodevices in a multicellular living organism10.7554/eLife.678302050-084Xe67830https://doaj.org/article/e17f89fffdfc4f8583ce3191789eed922021-07-01T00:00:00Zhttps://elifesciences.org/articles/67830https://doaj.org/toc/2050-084XNucleic acid nanodevices present great potential as agents for logic-based therapeutic intervention as well as in basic biology. Often, however, the disease targets that need corrective action are localized in specific organs, and thus realizing the full potential of DNA nanodevices also requires ways to target them to specific cell types in vivo. Here, we show that by exploiting either endogenous or synthetic receptor-ligand interactions and leveraging the biological barriers presented by the organism, we can target extraneously introduced DNA nanodevices to specific cell types in Caenorhabditis elegans, with subcellular precision. The amenability of DNA nanostructures to tissue-specific targeting in vivo significantly expands their utility in biomedical applications and discovery biology.Kasturi ChakrabortyPalapuravan AneesSunaina SuranaSimona MartinJihad AburasSandrine MoutelFranck PerezSandhya P KoushikaPaschalis KratsiosYamuna KrishnaneLife Sciences Publications LtdarticleDNA nanotechnologyendocytosislysosomescell membranelive imagingnematodesMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DNA nanotechnology endocytosis lysosomes cell membrane live imaging nematodes Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	DNA nanotechnology endocytosis lysosomes cell membrane live imaging nematodes Medicine R Science Q Biology (General) QH301-705.5 Kasturi Chakraborty Palapuravan Anees Sunaina Surana Simona Martin Jihad Aburas Sandrine Moutel Franck Perez Sandhya P Koushika Paschalis Kratsios Yamuna Krishnan Tissue-specific targeting of DNA nanodevices in a multicellular living organism
description	Nucleic acid nanodevices present great potential as agents for logic-based therapeutic intervention as well as in basic biology. Often, however, the disease targets that need corrective action are localized in specific organs, and thus realizing the full potential of DNA nanodevices also requires ways to target them to specific cell types in vivo. Here, we show that by exploiting either endogenous or synthetic receptor-ligand interactions and leveraging the biological barriers presented by the organism, we can target extraneously introduced DNA nanodevices to specific cell types in Caenorhabditis elegans, with subcellular precision. The amenability of DNA nanostructures to tissue-specific targeting in vivo significantly expands their utility in biomedical applications and discovery biology.
format	article
author	Kasturi Chakraborty Palapuravan Anees Sunaina Surana Simona Martin Jihad Aburas Sandrine Moutel Franck Perez Sandhya P Koushika Paschalis Kratsios Yamuna Krishnan
author_facet	Kasturi Chakraborty Palapuravan Anees Sunaina Surana Simona Martin Jihad Aburas Sandrine Moutel Franck Perez Sandhya P Koushika Paschalis Kratsios Yamuna Krishnan
author_sort	Kasturi Chakraborty
title	Tissue-specific targeting of DNA nanodevices in a multicellular living organism
title_short	Tissue-specific targeting of DNA nanodevices in a multicellular living organism
title_full	Tissue-specific targeting of DNA nanodevices in a multicellular living organism
title_fullStr	Tissue-specific targeting of DNA nanodevices in a multicellular living organism
title_full_unstemmed	Tissue-specific targeting of DNA nanodevices in a multicellular living organism
title_sort	tissue-specific targeting of dna nanodevices in a multicellular living organism
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/e17f89fffdfc4f8583ce3191789eed92
work_keys_str_mv	AT kasturichakraborty tissuespecifictargetingofdnananodevicesinamulticellularlivingorganism AT palapuravananees tissuespecifictargetingofdnananodevicesinamulticellularlivingorganism AT sunainasurana tissuespecifictargetingofdnananodevicesinamulticellularlivingorganism AT simonamartin tissuespecifictargetingofdnananodevicesinamulticellularlivingorganism AT jihadaburas tissuespecifictargetingofdnananodevicesinamulticellularlivingorganism AT sandrinemoutel tissuespecifictargetingofdnananodevicesinamulticellularlivingorganism AT franckperez tissuespecifictargetingofdnananodevicesinamulticellularlivingorganism AT sandhyapkoushika tissuespecifictargetingofdnananodevicesinamulticellularlivingorganism AT paschaliskratsios tissuespecifictargetingofdnananodevicesinamulticellularlivingorganism AT yamunakrishnan tissuespecifictargetingofdnananodevicesinamulticellularlivingorganism
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Tissue-specific targeting of DNA nanodevices in a multicellular living organism

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