NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

Cancer associated fibroblasts (CAFs) are known to promote pro-tumorigenic inflammation. Here, the authors show that CAFs sense tissue damage and activate NLRP3 inflammasome and pro-inflammatory IL-1β secretion, and CAF-derived inflammasome signalling promotes breast tumour growth and metastasis.

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Bibliographic Details
Main Authors: Nour Ershaid, Yoray Sharon, Hila Doron, Yael Raz, Ophir Shani, Noam Cohen, Lea Monteran, Leonor Leider-Trejo, Amir Ben-Shmuel, Muhammad Yassin, Motti Gerlic, Adit Ben-Baruch, Metsada Pasmanik-Chor, Roni Apte, Neta Erez
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
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Online Access:https://doaj.org/article/e17f97fa635942b78830a281b1c5e026
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Summary:Cancer associated fibroblasts (CAFs) are known to promote pro-tumorigenic inflammation. Here, the authors show that CAFs sense tissue damage and activate NLRP3 inflammasome and pro-inflammatory IL-1β secretion, and CAF-derived inflammasome signalling promotes breast tumour growth and metastasis.

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