NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

Cancer associated fibroblasts (CAFs) are known to promote pro-tumorigenic inflammation. Here, the authors show that CAFs sense tissue damage and activate NLRP3 inflammasome and pro-inflammatory IL-1β secretion, and CAF-derived inflammasome signalling promotes breast tumour growth and metastasis.

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Autores principales:	Nour Ershaid, Yoray Sharon, Hila Doron, Yael Raz, Ophir Shani, Noam Cohen, Lea Monteran, Leonor Leider-Trejo, Amir Ben-Shmuel, Muhammad Yassin, Motti Gerlic, Adit Ben-Baruch, Metsada Pasmanik-Chor, Roni Apte, Neta Erez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e17f97fa635942b78830a281b1c5e026
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spelling	oai:doaj.org-article:e17f97fa635942b78830a281b1c5e0262021-12-02T16:58:26ZNLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis10.1038/s41467-019-12370-82041-1723https://doaj.org/article/e17f97fa635942b78830a281b1c5e0262019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12370-8https://doaj.org/toc/2041-1723Cancer associated fibroblasts (CAFs) are known to promote pro-tumorigenic inflammation. Here, the authors show that CAFs sense tissue damage and activate NLRP3 inflammasome and pro-inflammatory IL-1β secretion, and CAF-derived inflammasome signalling promotes breast tumour growth and metastasis.Nour ErshaidYoray SharonHila DoronYael RazOphir ShaniNoam CohenLea MonteranLeonor Leider-TrejoAmir Ben-ShmuelMuhammad YassinMotti GerlicAdit Ben-BaruchMetsada Pasmanik-ChorRoni ApteNeta ErezNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nour Ershaid Yoray Sharon Hila Doron Yael Raz Ophir Shani Noam Cohen Lea Monteran Leonor Leider-Trejo Amir Ben-Shmuel Muhammad Yassin Motti Gerlic Adit Ben-Baruch Metsada Pasmanik-Chor Roni Apte Neta Erez NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis
description	Cancer associated fibroblasts (CAFs) are known to promote pro-tumorigenic inflammation. Here, the authors show that CAFs sense tissue damage and activate NLRP3 inflammasome and pro-inflammatory IL-1β secretion, and CAF-derived inflammasome signalling promotes breast tumour growth and metastasis.
format	article
author	Nour Ershaid Yoray Sharon Hila Doron Yael Raz Ophir Shani Noam Cohen Lea Monteran Leonor Leider-Trejo Amir Ben-Shmuel Muhammad Yassin Motti Gerlic Adit Ben-Baruch Metsada Pasmanik-Chor Roni Apte Neta Erez
author_facet	Nour Ershaid Yoray Sharon Hila Doron Yael Raz Ophir Shani Noam Cohen Lea Monteran Leonor Leider-Trejo Amir Ben-Shmuel Muhammad Yassin Motti Gerlic Adit Ben-Baruch Metsada Pasmanik-Chor Roni Apte Neta Erez
author_sort	Nour Ershaid
title	NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis
title_short	NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis
title_full	NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis
title_fullStr	NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis
title_full_unstemmed	NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis
title_sort	nlrp3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e17f97fa635942b78830a281b1c5e026
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NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

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