The influence of different intraocular pressure on lamina cribrosa parameters in glaucoma and the relation clinical implication

Abstract Elevated intraocular pressure (IOP) is one of the main risk factors for glaucoma, and pathological changes in the lamina cribrosa (LC) may play a leading role. This study aimed to explore the influence of different IOP on LC parameters and the correlation between parameters and glaucoma sev...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jian Wu, Yifan Du, Jiaying Li, Xiaowei Fan, Caixia Lin, Ningli Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e18789bd5f4e4951832515565c4ee325
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e18789bd5f4e4951832515565c4ee325
record_format	dspace
spelling	oai:doaj.org-article:e18789bd5f4e4951832515565c4ee3252021-12-02T15:38:23ZThe influence of different intraocular pressure on lamina cribrosa parameters in glaucoma and the relation clinical implication10.1038/s41598-021-87844-12045-2322https://doaj.org/article/e18789bd5f4e4951832515565c4ee3252021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87844-1https://doaj.org/toc/2045-2322Abstract Elevated intraocular pressure (IOP) is one of the main risk factors for glaucoma, and pathological changes in the lamina cribrosa (LC) may play a leading role. This study aimed to explore the influence of different IOP on LC parameters and the correlation between parameters and glaucoma severity. A total of 91 eyes were examined by swept-source OCT and divided into IOP ≥ 30 mmHg (group A), 21 mmHg ≤ IOP < 30 mmHg (group B), and normal IOP (control, group C). Clinical parameters and all LC parameters such as cup depth (CD), lamina cribrosa depth (LCD), prelaminar tissue thickness (PTT) and LC curvature index (LCCI) were used for statistical analysis. The bulk of parameters were greater in group A than in the other groups (group B, P < 0.05; group C, P < 0.001). PTT and Bruch’s membrane opening minimum rim width (BMO-MRW) were thinner in group A than in group C (P < 0.01). In univariate and multivariable linear regression analysis, visual field (VF), mean retinal nerve fiber layer (RNFL) thickness, CD, LCD, PLCSD, PTT, LCCI, aLCCI, and BMO-MRW were significantly correlated with IOP changes (P < 0.05). Pearson test showed that LCD and LCCI were correlated with mean retinal nerve fiber layer (RNFL) thickness (LCD, r = − 0.420, P = 0.002; LCCI, r = − 0.449, P < 0.001) and BMO-MRW (LCD, r = − 0.245, P = 0.019; LCCI, r = − 0.345, P < 0.001). Therefore, different levels of IOP have a remarkable effect on clinical symptoms (VF, BCVA) and LC parameters, between which there may be a linear relationship. LCCI may exhibit a more significant correlation with RNFL thickness and BMO-MRW, which may further suggest that LCCI shows a better correlation with clinical symptoms under the influence of long-term high IOP.Jian WuYifan DuJiaying LiXiaowei FanCaixia LinNingli WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian Wu Yifan Du Jiaying Li Xiaowei Fan Caixia Lin Ningli Wang The influence of different intraocular pressure on lamina cribrosa parameters in glaucoma and the relation clinical implication
description	Abstract Elevated intraocular pressure (IOP) is one of the main risk factors for glaucoma, and pathological changes in the lamina cribrosa (LC) may play a leading role. This study aimed to explore the influence of different IOP on LC parameters and the correlation between parameters and glaucoma severity. A total of 91 eyes were examined by swept-source OCT and divided into IOP ≥ 30 mmHg (group A), 21 mmHg ≤ IOP < 30 mmHg (group B), and normal IOP (control, group C). Clinical parameters and all LC parameters such as cup depth (CD), lamina cribrosa depth (LCD), prelaminar tissue thickness (PTT) and LC curvature index (LCCI) were used for statistical analysis. The bulk of parameters were greater in group A than in the other groups (group B, P < 0.05; group C, P < 0.001). PTT and Bruch’s membrane opening minimum rim width (BMO-MRW) were thinner in group A than in group C (P < 0.01). In univariate and multivariable linear regression analysis, visual field (VF), mean retinal nerve fiber layer (RNFL) thickness, CD, LCD, PLCSD, PTT, LCCI, aLCCI, and BMO-MRW were significantly correlated with IOP changes (P < 0.05). Pearson test showed that LCD and LCCI were correlated with mean retinal nerve fiber layer (RNFL) thickness (LCD, r = − 0.420, P = 0.002; LCCI, r = − 0.449, P < 0.001) and BMO-MRW (LCD, r = − 0.245, P = 0.019; LCCI, r = − 0.345, P < 0.001). Therefore, different levels of IOP have a remarkable effect on clinical symptoms (VF, BCVA) and LC parameters, between which there may be a linear relationship. LCCI may exhibit a more significant correlation with RNFL thickness and BMO-MRW, which may further suggest that LCCI shows a better correlation with clinical symptoms under the influence of long-term high IOP.
format	article
author	Jian Wu Yifan Du Jiaying Li Xiaowei Fan Caixia Lin Ningli Wang
author_facet	Jian Wu Yifan Du Jiaying Li Xiaowei Fan Caixia Lin Ningli Wang
author_sort	Jian Wu
title	The influence of different intraocular pressure on lamina cribrosa parameters in glaucoma and the relation clinical implication
title_short	The influence of different intraocular pressure on lamina cribrosa parameters in glaucoma and the relation clinical implication
title_full	The influence of different intraocular pressure on lamina cribrosa parameters in glaucoma and the relation clinical implication
title_fullStr	The influence of different intraocular pressure on lamina cribrosa parameters in glaucoma and the relation clinical implication
title_full_unstemmed	The influence of different intraocular pressure on lamina cribrosa parameters in glaucoma and the relation clinical implication
title_sort	influence of different intraocular pressure on lamina cribrosa parameters in glaucoma and the relation clinical implication
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e18789bd5f4e4951832515565c4ee325
work_keys_str_mv	AT jianwu theinfluenceofdifferentintraocularpressureonlaminacribrosaparametersinglaucomaandtherelationclinicalimplication AT yifandu theinfluenceofdifferentintraocularpressureonlaminacribrosaparametersinglaucomaandtherelationclinicalimplication AT jiayingli theinfluenceofdifferentintraocularpressureonlaminacribrosaparametersinglaucomaandtherelationclinicalimplication AT xiaoweifan theinfluenceofdifferentintraocularpressureonlaminacribrosaparametersinglaucomaandtherelationclinicalimplication AT caixialin theinfluenceofdifferentintraocularpressureonlaminacribrosaparametersinglaucomaandtherelationclinicalimplication AT ningliwang theinfluenceofdifferentintraocularpressureonlaminacribrosaparametersinglaucomaandtherelationclinicalimplication AT jianwu influenceofdifferentintraocularpressureonlaminacribrosaparametersinglaucomaandtherelationclinicalimplication AT yifandu influenceofdifferentintraocularpressureonlaminacribrosaparametersinglaucomaandtherelationclinicalimplication AT jiayingli influenceofdifferentintraocularpressureonlaminacribrosaparametersinglaucomaandtherelationclinicalimplication AT xiaoweifan influenceofdifferentintraocularpressureonlaminacribrosaparametersinglaucomaandtherelationclinicalimplication AT caixialin influenceofdifferentintraocularpressureonlaminacribrosaparametersinglaucomaandtherelationclinicalimplication AT ningliwang influenceofdifferentintraocularpressureonlaminacribrosaparametersinglaucomaandtherelationclinicalimplication
_version_	1718386204829810688

The influence of different intraocular pressure on lamina cribrosa parameters in glaucoma and the relation clinical implication

Ejemplares similares