Evidence from oyster suggests an ancient role for Pdx in regulating insulin gene expression in animals

In vertebrates insulin is a direct transcriptional target of Pdx: the same is true in Pacific oysters and the authors show insulin-related gene, cgILP, is co-expressed with cgPdx in oyster digestive tissue, showing this gene interaction dates back to the origin of Bilateria.

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Main Authors:	Fei Xu, Ferdinand Marlétaz, Daria Gavriouchkina, Xiao Liu, Tatjana Sauka-Spengler, Guofan Zhang, Peter W. H. Holland
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/e18b9c5e76e6411fadb36ce6496f1dd9
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spelling	oai:doaj.org-article:e18b9c5e76e6411fadb36ce6496f1dd92021-12-02T14:49:08ZEvidence from oyster suggests an ancient role for Pdx in regulating insulin gene expression in animals10.1038/s41467-021-23216-72041-1723https://doaj.org/article/e18b9c5e76e6411fadb36ce6496f1dd92021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23216-7https://doaj.org/toc/2041-1723In vertebrates insulin is a direct transcriptional target of Pdx: the same is true in Pacific oysters and the authors show insulin-related gene, cgILP, is co-expressed with cgPdx in oyster digestive tissue, showing this gene interaction dates back to the origin of Bilateria.Fei XuFerdinand MarlétazDaria GavriouchkinaXiao LiuTatjana Sauka-SpenglerGuofan ZhangPeter W. H. HollandNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fei Xu Ferdinand Marlétaz Daria Gavriouchkina Xiao Liu Tatjana Sauka-Spengler Guofan Zhang Peter W. H. Holland Evidence from oyster suggests an ancient role for Pdx in regulating insulin gene expression in animals
description	In vertebrates insulin is a direct transcriptional target of Pdx: the same is true in Pacific oysters and the authors show insulin-related gene, cgILP, is co-expressed with cgPdx in oyster digestive tissue, showing this gene interaction dates back to the origin of Bilateria.
format	article
author	Fei Xu Ferdinand Marlétaz Daria Gavriouchkina Xiao Liu Tatjana Sauka-Spengler Guofan Zhang Peter W. H. Holland
author_facet	Fei Xu Ferdinand Marlétaz Daria Gavriouchkina Xiao Liu Tatjana Sauka-Spengler Guofan Zhang Peter W. H. Holland
author_sort	Fei Xu
title	Evidence from oyster suggests an ancient role for Pdx in regulating insulin gene expression in animals
title_short	Evidence from oyster suggests an ancient role for Pdx in regulating insulin gene expression in animals
title_full	Evidence from oyster suggests an ancient role for Pdx in regulating insulin gene expression in animals
title_fullStr	Evidence from oyster suggests an ancient role for Pdx in regulating insulin gene expression in animals
title_full_unstemmed	Evidence from oyster suggests an ancient role for Pdx in regulating insulin gene expression in animals
title_sort	evidence from oyster suggests an ancient role for pdx in regulating insulin gene expression in animals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e18b9c5e76e6411fadb36ce6496f1dd9
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Evidence from oyster suggests an ancient role for Pdx in regulating insulin gene expression in animals

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