ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS

Periodontitis is a chronic infectious inflammatory disease, being the most common bone disease in humans. Porphyromonas gingivalis bacteria are quite common in periodontal lesions, thus considered among major causal agents of periodontitis. Monocytes play a crucial role in development of the infecti...

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Autores principales:	L. M. Tebloeva, O. A. Guseva, S. V. Philippov, S. V. Khaidukov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	flow cytometry monocytes periodontitis cd14 cd16 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e18cc7bbee3646db8ac9ef09e7ba7acd
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spelling	oai:doaj.org-article:e18cc7bbee3646db8ac9ef09e7ba7acd2021-11-18T08:03:43ZACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS1563-06252313-741X10.15789/1563-0625-2014-2-165-172https://doaj.org/article/e18cc7bbee3646db8ac9ef09e7ba7acd2014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/682https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XPeriodontitis is a chronic infectious inflammatory disease, being the most common bone disease in humans. Porphyromonas gingivalis bacteria are quite common in periodontal lesions, thus considered among major causal agents of periodontitis. Monocytes play a crucial role in development of the infectious events and subsequent inflammation. The aim of this study was to investigate appropriate changes of the monocyte subpopulations, as well as to assess relationships between expression of CD14, CD16, CD45RA, HLA-DR on the monocyte surfaces in the patients with periodontitis. It was demonstrated that periodontitis is accompanied by increased counts of pro-inflammatory monocytes. These changes are characterized by decreased expression of CD14, along with occurence of CD16 marker. Concomitant activation of the monocytes is reflected by CD45RA expression. However, in spite of significant increase in CD14lowCD16+HLA-DR+ cell counts observed in patients with periodontitis, these monocyte populations are not likely to play a significant role in development of a specific immune response and suppression of periodontitis.L. M. TebloevaO. A. GusevaS. V. PhilippovS. V. KhaidukovSPb RAACIarticleflow cytometrymonocytesperiodontitiscd14cd16Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 2, Pp 165-172 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	flow cytometry monocytes periodontitis cd14 cd16 Immunologic diseases. Allergy RC581-607
spellingShingle	flow cytometry monocytes periodontitis cd14 cd16 Immunologic diseases. Allergy RC581-607 L. M. Tebloeva O. A. Guseva S. V. Philippov S. V. Khaidukov ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS
description	Periodontitis is a chronic infectious inflammatory disease, being the most common bone disease in humans. Porphyromonas gingivalis bacteria are quite common in periodontal lesions, thus considered among major causal agents of periodontitis. Monocytes play a crucial role in development of the infectious events and subsequent inflammation. The aim of this study was to investigate appropriate changes of the monocyte subpopulations, as well as to assess relationships between expression of CD14, CD16, CD45RA, HLA-DR on the monocyte surfaces in the patients with periodontitis. It was demonstrated that periodontitis is accompanied by increased counts of pro-inflammatory monocytes. These changes are characterized by decreased expression of CD14, along with occurence of CD16 marker. Concomitant activation of the monocytes is reflected by CD45RA expression. However, in spite of significant increase in CD14lowCD16+HLA-DR+ cell counts observed in patients with periodontitis, these monocyte populations are not likely to play a significant role in development of a specific immune response and suppression of periodontitis.
format	article
author	L. M. Tebloeva O. A. Guseva S. V. Philippov S. V. Khaidukov
author_facet	L. M. Tebloeva O. A. Guseva S. V. Philippov S. V. Khaidukov
author_sort	L. M. Tebloeva
title	ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS
title_short	ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS
title_full	ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS
title_fullStr	ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS
title_full_unstemmed	ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS
title_sort	activation and differentiation of peripheral blood monocytes in periodontitis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/e18cc7bbee3646db8ac9ef09e7ba7acd
work_keys_str_mv	AT lmtebloeva activationanddifferentiationofperipheralbloodmonocytesinperiodontitis AT oaguseva activationanddifferentiationofperipheralbloodmonocytesinperiodontitis AT svphilippov activationanddifferentiationofperipheralbloodmonocytesinperiodontitis AT svkhaidukov activationanddifferentiationofperipheralbloodmonocytesinperiodontitis
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ACTIVATION AND DIFFERENTIATION OF PERIPHERAL BLOOD MONOCYTES IN PERIODONTITIS

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