Pediatric visceral leishmaniasis in Tartous, Syria

Background: Visceral leishmaniasis (VL) type in Syria is Lashmania infantum, a fatal incapacitating disease, which is mostly seen in infants. Subjects and Methods: Hospital records of 19 children with VL were retrospectively reviewed. The period of the study was from June 2016 to July 2019. Results:...

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Autores principales:	Ali Othman Hamwi, Ali Abdallatif Mohammad, Sara Othman Hamwi, Razan Abdallatif Mohammad, Kayss Younis Shahin
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2020
Materias:	children leishmania infantum meglumine antimonate pediatric visceral leishmaniasis Medicine R
Acceso en línea:	https://doaj.org/article/e18f45ba8e7d44f190e76ff207e8ff0e
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spelling	oai:doaj.org-article:e18f45ba8e7d44f190e76ff207e8ff0e2021-12-02T15:06:48ZPediatric visceral leishmaniasis in Tartous, Syria2231-07702249-446410.4103/ajm.ajm_168_20https://doaj.org/article/e18f45ba8e7d44f190e76ff207e8ff0e2020-10-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/ajm.ajm_168_20https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464Background: Visceral leishmaniasis (VL) type in Syria is Lashmania infantum, a fatal incapacitating disease, which is mostly seen in infants. Subjects and Methods: Hospital records of 19 children with VL were retrospectively reviewed. The period of the study was from June 2016 to July 2019. Results: The median age of the patients was 45.5 months. None was coinfected with human immunodeficiency virus or known to be immunocompromised. Pallor and anemia were observed in all cases, fever in 13 (68.42%), splenomegaly in 18 (94.7%), hepatomegaly in 11 (57.9%), thrombocytopenia in 15 (78.95%), and leukopenia in nine (47.4%). A bone marrow aspirate was obtained and Leishmania amastigotes were detected in all patients. All patients were initially treated with meglumine antimonate; one child did not respond and was treated with lipid formulations of amphotericin B. Conclusions: Presentation of VL in the pediatric age group is characterized by pallor, fever, splenomegaly, and hepatomegaly. Hematological and biochemical indices are typical with cytopenias. In all cases, microscopic examination provided a positive diagnosis. Despite recent reports on decreased responses to antimonial drugs of patients with Mediterranean VL, meglumine antimonate treatment appears to be still highly effective in Syria.Ali Othman HamwiAli Abdallatif MohammadSara Othman HamwiRazan Abdallatif MohammadKayss Younis ShahinThieme Medical and Scientific Publishers Pvt. Ltd.articlechildrenleishmania infantummeglumine antimonatepediatricvisceral leishmaniasisMedicineRENAvicenna Journal of Medicine, Vol 10, Iss 04, Pp 223-226 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	children leishmania infantum meglumine antimonate pediatric visceral leishmaniasis Medicine R
spellingShingle	children leishmania infantum meglumine antimonate pediatric visceral leishmaniasis Medicine R Ali Othman Hamwi Ali Abdallatif Mohammad Sara Othman Hamwi Razan Abdallatif Mohammad Kayss Younis Shahin Pediatric visceral leishmaniasis in Tartous, Syria
description	Background: Visceral leishmaniasis (VL) type in Syria is Lashmania infantum, a fatal incapacitating disease, which is mostly seen in infants. Subjects and Methods: Hospital records of 19 children with VL were retrospectively reviewed. The period of the study was from June 2016 to July 2019. Results: The median age of the patients was 45.5 months. None was coinfected with human immunodeficiency virus or known to be immunocompromised. Pallor and anemia were observed in all cases, fever in 13 (68.42%), splenomegaly in 18 (94.7%), hepatomegaly in 11 (57.9%), thrombocytopenia in 15 (78.95%), and leukopenia in nine (47.4%). A bone marrow aspirate was obtained and Leishmania amastigotes were detected in all patients. All patients were initially treated with meglumine antimonate; one child did not respond and was treated with lipid formulations of amphotericin B. Conclusions: Presentation of VL in the pediatric age group is characterized by pallor, fever, splenomegaly, and hepatomegaly. Hematological and biochemical indices are typical with cytopenias. In all cases, microscopic examination provided a positive diagnosis. Despite recent reports on decreased responses to antimonial drugs of patients with Mediterranean VL, meglumine antimonate treatment appears to be still highly effective in Syria.
format	article
author	Ali Othman Hamwi Ali Abdallatif Mohammad Sara Othman Hamwi Razan Abdallatif Mohammad Kayss Younis Shahin
author_facet	Ali Othman Hamwi Ali Abdallatif Mohammad Sara Othman Hamwi Razan Abdallatif Mohammad Kayss Younis Shahin
author_sort	Ali Othman Hamwi
title	Pediatric visceral leishmaniasis in Tartous, Syria
title_short	Pediatric visceral leishmaniasis in Tartous, Syria
title_full	Pediatric visceral leishmaniasis in Tartous, Syria
title_fullStr	Pediatric visceral leishmaniasis in Tartous, Syria
title_full_unstemmed	Pediatric visceral leishmaniasis in Tartous, Syria
title_sort	pediatric visceral leishmaniasis in tartous, syria
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2020
url	https://doaj.org/article/e18f45ba8e7d44f190e76ff207e8ff0e
work_keys_str_mv	AT aliothmanhamwi pediatricvisceralleishmaniasisintartoussyria AT aliabdallatifmohammad pediatricvisceralleishmaniasisintartoussyria AT saraothmanhamwi pediatricvisceralleishmaniasisintartoussyria AT razanabdallatifmohammad pediatricvisceralleishmaniasisintartoussyria AT kayssyounisshahin pediatricvisceralleishmaniasisintartoussyria
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Pediatric visceral leishmaniasis in Tartous, Syria

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