Metabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered E. coli

Synthetic pathways represent a metabolic burden on host cells. Here the authors engineer Cra-binding sites to prevent misregulation in glycerol and carotenoid overproducing E. coli strains.

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Autores principales:	Chun-Ying Wang, Martin Lempp, Niklas Farke, Stefano Donati, Timo Glatter, Hannes Link
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e191ae102d374078b676c6a807f7a206
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spelling	oai:doaj.org-article:e191ae102d374078b676c6a807f7a2062021-12-02T16:28:01ZMetabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered E. coli10.1038/s41467-021-25142-02041-1723https://doaj.org/article/e191ae102d374078b676c6a807f7a2062021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25142-0https://doaj.org/toc/2041-1723Synthetic pathways represent a metabolic burden on host cells. Here the authors engineer Cra-binding sites to prevent misregulation in glycerol and carotenoid overproducing E. coli strains.Chun-Ying WangMartin LemppNiklas FarkeStefano DonatiTimo GlatterHannes LinkNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chun-Ying Wang Martin Lempp Niklas Farke Stefano Donati Timo Glatter Hannes Link Metabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered E. coli
description	Synthetic pathways represent a metabolic burden on host cells. Here the authors engineer Cra-binding sites to prevent misregulation in glycerol and carotenoid overproducing E. coli strains.
format	article
author	Chun-Ying Wang Martin Lempp Niklas Farke Stefano Donati Timo Glatter Hannes Link
author_facet	Chun-Ying Wang Martin Lempp Niklas Farke Stefano Donati Timo Glatter Hannes Link
author_sort	Chun-Ying Wang
title	Metabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered E. coli
title_short	Metabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered E. coli
title_full	Metabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered E. coli
title_fullStr	Metabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered E. coli
title_full_unstemmed	Metabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered E. coli
title_sort	metabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered e. coli
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e191ae102d374078b676c6a807f7a206
work_keys_str_mv	AT chunyingwang metabolomeandproteomeanalysesrevealtranscriptionalmisregulationinglycolysisofengineeredecoli AT martinlempp metabolomeandproteomeanalysesrevealtranscriptionalmisregulationinglycolysisofengineeredecoli AT niklasfarke metabolomeandproteomeanalysesrevealtranscriptionalmisregulationinglycolysisofengineeredecoli AT stefanodonati metabolomeandproteomeanalysesrevealtranscriptionalmisregulationinglycolysisofengineeredecoli AT timoglatter metabolomeandproteomeanalysesrevealtranscriptionalmisregulationinglycolysisofengineeredecoli AT hanneslink metabolomeandproteomeanalysesrevealtranscriptionalmisregulationinglycolysisofengineeredecoli
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Metabolome and proteome analyses reveal transcriptional misregulation in glycolysis of engineered E. coli

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