Doxycycline promotes proteasome fitness in the central nervous system

Doxycycline promotes proteasome fitness in the central nervous system

Abstract Several studies reported that mitochondrial stress induces cytosolic proteostasis in yeast and C. elegans. Notably, inhibition of mitochondrial translation with doxcycyline decreases the toxicity of β-amyloid aggregates, in a C. elegans. However, how mitochondrial stress activates cytosolic...

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Autores principales: Edmund Charles Jenkins, Matthew J. O’Connell, Giovanni Manfredi, Doris Germain
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/e192bb23a88c41f3aa470441a552b7ef
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