Molecular basis for chirality-regulated Aβ self-assembly and receptor recognition revealed by ion mobility-mass spectrometry

Chiral inversion of amino acids is thought to modulate the structure and function of amyloid beta (Aβ) but these processes are poorly understood. Here, the authors develop an ion mobility-mass spectrometry based approach to study chirality-regulated structural features of Aβ fragments and their infl...

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Autores principales:	Gongyu Li, Kellen DeLaney, Lingjun Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e1966d5c12e14ee2889bec41b268dddb
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spelling	oai:doaj.org-article:e1966d5c12e14ee2889bec41b268dddb2021-12-02T15:35:10ZMolecular basis for chirality-regulated Aβ self-assembly and receptor recognition revealed by ion mobility-mass spectrometry10.1038/s41467-019-12346-82041-1723https://doaj.org/article/e1966d5c12e14ee2889bec41b268dddb2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12346-8https://doaj.org/toc/2041-1723Chiral inversion of amino acids is thought to modulate the structure and function of amyloid beta (Aβ) but these processes are poorly understood. Here, the authors develop an ion mobility-mass spectrometry based approach to study chirality-regulated structural features of Aβ fragments and their influence on receptor recognition.Gongyu LiKellen DeLaneyLingjun LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gongyu Li Kellen DeLaney Lingjun Li Molecular basis for chirality-regulated Aβ self-assembly and receptor recognition revealed by ion mobility-mass spectrometry
description	Chiral inversion of amino acids is thought to modulate the structure and function of amyloid beta (Aβ) but these processes are poorly understood. Here, the authors develop an ion mobility-mass spectrometry based approach to study chirality-regulated structural features of Aβ fragments and their influence on receptor recognition.
format	article
author	Gongyu Li Kellen DeLaney Lingjun Li
author_facet	Gongyu Li Kellen DeLaney Lingjun Li
author_sort	Gongyu Li
title	Molecular basis for chirality-regulated Aβ self-assembly and receptor recognition revealed by ion mobility-mass spectrometry
title_short	Molecular basis for chirality-regulated Aβ self-assembly and receptor recognition revealed by ion mobility-mass spectrometry
title_full	Molecular basis for chirality-regulated Aβ self-assembly and receptor recognition revealed by ion mobility-mass spectrometry
title_fullStr	Molecular basis for chirality-regulated Aβ self-assembly and receptor recognition revealed by ion mobility-mass spectrometry
title_full_unstemmed	Molecular basis for chirality-regulated Aβ self-assembly and receptor recognition revealed by ion mobility-mass spectrometry
title_sort	molecular basis for chirality-regulated aβ self-assembly and receptor recognition revealed by ion mobility-mass spectrometry
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e1966d5c12e14ee2889bec41b268dddb
work_keys_str_mv	AT gongyuli molecularbasisforchiralityregulatedabselfassemblyandreceptorrecognitionrevealedbyionmobilitymassspectrometry AT kellendelaney molecularbasisforchiralityregulatedabselfassemblyandreceptorrecognitionrevealedbyionmobilitymassspectrometry AT lingjunli molecularbasisforchiralityregulatedabselfassemblyandreceptorrecognitionrevealedbyionmobilitymassspectrometry
_version_	1718386690637168640

Molecular basis for chirality-regulated Aβ self-assembly and receptor recognition revealed by ion mobility-mass spectrometry

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