Burden of kidney failure from atheroembolic disease and association with survival in people receiving dialysis in Australia and New Zealand: a multi-centre registry study

Abstract Background Cardiovascular disease is a leading cause of mortality in kidney failure (KF). Patients with KF from atheroembolic disease are at higher risk of cardiovascular disease than other causes of KF. This study aimed to determine survival on dialysis for patients with KF from atheroembo...

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Autores principales:	Tahira Scott, Isabelle Ethier, Carmel Hawley, Elaine M. Pascoe, Andrea K. Viecelli, Arnold Ng, Yeoungjee Cho, David W. Johnson
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Atheroembolic disease Dialysis Kidney failure Outcome Registry Survival Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/e19b999fb9f74275810c030eb5a56b7e
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spelling	oai:doaj.org-article:e19b999fb9f74275810c030eb5a56b7e2021-12-05T12:26:03ZBurden of kidney failure from atheroembolic disease and association with survival in people receiving dialysis in Australia and New Zealand: a multi-centre registry study10.1186/s12882-021-02604-71471-2369https://doaj.org/article/e19b999fb9f74275810c030eb5a56b7e2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12882-021-02604-7https://doaj.org/toc/1471-2369Abstract Background Cardiovascular disease is a leading cause of mortality in kidney failure (KF). Patients with KF from atheroembolic disease are at higher risk of cardiovascular disease than other causes of KF. This study aimed to determine survival on dialysis for patients with KF from atheroembolic disease compared with other causes of KF. Methods All adults (≥ 18 years) with KF initiating dialysis as the first kidney replacement therapy between 1 January 1990 and 31 December 2017 according to the Australia and New Zealand Dialysis and Transplant registry were included. Patients were grouped into either: KF from atheroembolic disease and all other causes of KF. Survival outcomes were assessed by the Kaplan-Meier method and Cox regression analysis adjusted for patient-related characteristics. Results Among 65,266 people on dialysis during the study period, 334 (0.5%) patients had KF from atheroembolic disease. A decreasing annual incidence of KF from atheroembolic disease was observed from 2008 onwards. Individuals with KF from atheroembolic disease demonstrated worse survival on dialysis compared to those with other causes of KF (HR 1.80, 95% confidence interval [CI] 1.61–2.03). The respective one- and five-year survival rates were 77 and 23% for KF from atheroembolic disease and 88 and 47% for other causes of KF. After adjustment for patient characteristics, KF from atheroembolic disease was not associated with increased patient mortality (adjusted HR 0.93 95% CI 0.82–1.05). Conclusions Survival outcomes on dialysis are worse for individuals with KF from atheroembolic disease compared to those with other causes of KF, probably due to patient demographics and higher comorbidity.Tahira ScottIsabelle EthierCarmel HawleyElaine M. PascoeAndrea K. ViecelliArnold NgYeoungjee ChoDavid W. JohnsonBMCarticleAtheroembolic diseaseDialysisKidney failureOutcomeRegistrySurvivalDiseases of the genitourinary system. UrologyRC870-923ENBMC Nephrology, Vol 22, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Atheroembolic disease Dialysis Kidney failure Outcome Registry Survival Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Atheroembolic disease Dialysis Kidney failure Outcome Registry Survival Diseases of the genitourinary system. Urology RC870-923 Tahira Scott Isabelle Ethier Carmel Hawley Elaine M. Pascoe Andrea K. Viecelli Arnold Ng Yeoungjee Cho David W. Johnson Burden of kidney failure from atheroembolic disease and association with survival in people receiving dialysis in Australia and New Zealand: a multi-centre registry study
description	Abstract Background Cardiovascular disease is a leading cause of mortality in kidney failure (KF). Patients with KF from atheroembolic disease are at higher risk of cardiovascular disease than other causes of KF. This study aimed to determine survival on dialysis for patients with KF from atheroembolic disease compared with other causes of KF. Methods All adults (≥ 18 years) with KF initiating dialysis as the first kidney replacement therapy between 1 January 1990 and 31 December 2017 according to the Australia and New Zealand Dialysis and Transplant registry were included. Patients were grouped into either: KF from atheroembolic disease and all other causes of KF. Survival outcomes were assessed by the Kaplan-Meier method and Cox regression analysis adjusted for patient-related characteristics. Results Among 65,266 people on dialysis during the study period, 334 (0.5%) patients had KF from atheroembolic disease. A decreasing annual incidence of KF from atheroembolic disease was observed from 2008 onwards. Individuals with KF from atheroembolic disease demonstrated worse survival on dialysis compared to those with other causes of KF (HR 1.80, 95% confidence interval [CI] 1.61–2.03). The respective one- and five-year survival rates were 77 and 23% for KF from atheroembolic disease and 88 and 47% for other causes of KF. After adjustment for patient characteristics, KF from atheroembolic disease was not associated with increased patient mortality (adjusted HR 0.93 95% CI 0.82–1.05). Conclusions Survival outcomes on dialysis are worse for individuals with KF from atheroembolic disease compared to those with other causes of KF, probably due to patient demographics and higher comorbidity.
format	article
author	Tahira Scott Isabelle Ethier Carmel Hawley Elaine M. Pascoe Andrea K. Viecelli Arnold Ng Yeoungjee Cho David W. Johnson
author_facet	Tahira Scott Isabelle Ethier Carmel Hawley Elaine M. Pascoe Andrea K. Viecelli Arnold Ng Yeoungjee Cho David W. Johnson
author_sort	Tahira Scott
title	Burden of kidney failure from atheroembolic disease and association with survival in people receiving dialysis in Australia and New Zealand: a multi-centre registry study
title_short	Burden of kidney failure from atheroembolic disease and association with survival in people receiving dialysis in Australia and New Zealand: a multi-centre registry study
title_full	Burden of kidney failure from atheroembolic disease and association with survival in people receiving dialysis in Australia and New Zealand: a multi-centre registry study
title_fullStr	Burden of kidney failure from atheroembolic disease and association with survival in people receiving dialysis in Australia and New Zealand: a multi-centre registry study
title_full_unstemmed	Burden of kidney failure from atheroembolic disease and association with survival in people receiving dialysis in Australia and New Zealand: a multi-centre registry study
title_sort	burden of kidney failure from atheroembolic disease and association with survival in people receiving dialysis in australia and new zealand: a multi-centre registry study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e19b999fb9f74275810c030eb5a56b7e
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Burden of kidney failure from atheroembolic disease and association with survival in people receiving dialysis in Australia and New Zealand: a multi-centre registry study

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