Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation

Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation

Type II alveolar cells play central roles in multiple aspects of lung biology. Here the authors show that type II alveolar cells also constitutively express MHCII, exhibit limited MHCII antigen presentation capacity, and are a component of the host response to respiratory viral infection.

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Bibliographic Details
Main Authors: Sushila A. Toulmin, Chaitali Bhadiadra, Andrew J. Paris, Jeffrey H. Lin, Jeremy Katzen, Maria C. Basil, Edward E. Morrisey, G. Scott Worthen, Laurence C. Eisenlohr
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/e19c792b6eed4c79a384d45bab80f5de
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Summary:Type II alveolar cells play central roles in multiple aspects of lung biology. Here the authors show that type II alveolar cells also constitutively express MHCII, exhibit limited MHCII antigen presentation capacity, and are a component of the host response to respiratory viral infection.

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