Heart Failure and Ischemic Stroke: A Bidirectional and Multivariable Mendelian Randomization Study
Background: Heart failure (HF) is a potential cause of ischemic stroke (IS), and previous studies have reported an association between HF and IS. This study aimed to analyze the causal link between HF and IS using bidirectional and multivariable Mendelian randomization (MR) studies.Methods: Genetic...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:e1a0b076acfa4aa8aa54188a541fe7df2021-12-01T11:59:31ZHeart Failure and Ischemic Stroke: A Bidirectional and Multivariable Mendelian Randomization Study1664-802110.3389/fgene.2021.771044https://doaj.org/article/e1a0b076acfa4aa8aa54188a541fe7df2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.771044/fullhttps://doaj.org/toc/1664-8021Background: Heart failure (HF) is a potential cause of ischemic stroke (IS), and previous studies have reported an association between HF and IS. This study aimed to analyze the causal link between HF and IS using bidirectional and multivariable Mendelian randomization (MR) studies.Methods: Genetic variants significantly associated with HF and IS were selected in the MR analysis from two large genome-wide association studies. Bidirectional and multivariable MR analyses were performed to evaluate the effect of HF on IS or the effect of IS on HF.Results: Two-sample MR analysis showed causal effects of HF on IS of all causes [odds ratio (OR) = 1.555, 95% confidence interval (CI): 1.343–1.799, p = 3.35 × 10−9] and large artery atherosclerosis stroke (LAS) (OR = 1.678, 95% CI: 1.044–2.696, p = 3.03 × 10−5), while there was a suggestive effect of HF on cardioembolic stroke (CES) (OR = 3.355, 95% CI: 1.031–10.919, p = 0.044). Genetically predicted HF was not associated with small artery occlusion stroke. Bidirectional MR analysis showed causal effects of IS of all causes (OR = 1.211, 95% CI: 1.040–1.410, p = 0.014) and CES (OR = 1.277, 95% CI: 1.213–1.344, p = 6.73 × 10−21) on HF, while there were no causal effects of LAS on HF.Conclusion: This MR analysis provided evidence of the causal links between genetically predicted HF and IS. Subgroup analysis highlighted the causal or suggestive relationship between genetically predicted HF and LAS or CES. The potential causal links need further investigation with genetic information about other ancestries or etiologies of HF.Luyang ZhangLuyang ZhangWeishi LiuWeishi LiuWeishi LiuWenxian SunWenxian SunXin WangXin WangMengke TianMengke TianLu-Lu PeiLu-Lu PeiKai LiuKai LiuJing LiangJing LiangLue ZhouLue ZhouJie LuMingming NingFerdinando S. BuonannoYuming XuYuming XuBo SongBo SongFrontiers Media S.A.articleheart failureischemic strokesingle nucleotide polymorphismmendelian randomizationstrokeGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021) |
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| topic |
heart failure ischemic stroke single nucleotide polymorphism mendelian randomization stroke Genetics QH426-470 |
| spellingShingle |
heart failure ischemic stroke single nucleotide polymorphism mendelian randomization stroke Genetics QH426-470 Luyang Zhang Luyang Zhang Weishi Liu Weishi Liu Weishi Liu Wenxian Sun Wenxian Sun Xin Wang Xin Wang Mengke Tian Mengke Tian Lu-Lu Pei Lu-Lu Pei Kai Liu Kai Liu Jing Liang Jing Liang Lue Zhou Lue Zhou Jie Lu Mingming Ning Ferdinando S. Buonanno Yuming Xu Yuming Xu Bo Song Bo Song Heart Failure and Ischemic Stroke: A Bidirectional and Multivariable Mendelian Randomization Study |
| description |
Background: Heart failure (HF) is a potential cause of ischemic stroke (IS), and previous studies have reported an association between HF and IS. This study aimed to analyze the causal link between HF and IS using bidirectional and multivariable Mendelian randomization (MR) studies.Methods: Genetic variants significantly associated with HF and IS were selected in the MR analysis from two large genome-wide association studies. Bidirectional and multivariable MR analyses were performed to evaluate the effect of HF on IS or the effect of IS on HF.Results: Two-sample MR analysis showed causal effects of HF on IS of all causes [odds ratio (OR) = 1.555, 95% confidence interval (CI): 1.343–1.799, p = 3.35 × 10−9] and large artery atherosclerosis stroke (LAS) (OR = 1.678, 95% CI: 1.044–2.696, p = 3.03 × 10−5), while there was a suggestive effect of HF on cardioembolic stroke (CES) (OR = 3.355, 95% CI: 1.031–10.919, p = 0.044). Genetically predicted HF was not associated with small artery occlusion stroke. Bidirectional MR analysis showed causal effects of IS of all causes (OR = 1.211, 95% CI: 1.040–1.410, p = 0.014) and CES (OR = 1.277, 95% CI: 1.213–1.344, p = 6.73 × 10−21) on HF, while there were no causal effects of LAS on HF.Conclusion: This MR analysis provided evidence of the causal links between genetically predicted HF and IS. Subgroup analysis highlighted the causal or suggestive relationship between genetically predicted HF and LAS or CES. The potential causal links need further investigation with genetic information about other ancestries or etiologies of HF. |
| format |
article |
| author |
Luyang Zhang Luyang Zhang Weishi Liu Weishi Liu Weishi Liu Wenxian Sun Wenxian Sun Xin Wang Xin Wang Mengke Tian Mengke Tian Lu-Lu Pei Lu-Lu Pei Kai Liu Kai Liu Jing Liang Jing Liang Lue Zhou Lue Zhou Jie Lu Mingming Ning Ferdinando S. Buonanno Yuming Xu Yuming Xu Bo Song Bo Song |
| author_facet |
Luyang Zhang Luyang Zhang Weishi Liu Weishi Liu Weishi Liu Wenxian Sun Wenxian Sun Xin Wang Xin Wang Mengke Tian Mengke Tian Lu-Lu Pei Lu-Lu Pei Kai Liu Kai Liu Jing Liang Jing Liang Lue Zhou Lue Zhou Jie Lu Mingming Ning Ferdinando S. Buonanno Yuming Xu Yuming Xu Bo Song Bo Song |
| author_sort |
Luyang Zhang |
| title |
Heart Failure and Ischemic Stroke: A Bidirectional and Multivariable Mendelian Randomization Study |
| title_short |
Heart Failure and Ischemic Stroke: A Bidirectional and Multivariable Mendelian Randomization Study |
| title_full |
Heart Failure and Ischemic Stroke: A Bidirectional and Multivariable Mendelian Randomization Study |
| title_fullStr |
Heart Failure and Ischemic Stroke: A Bidirectional and Multivariable Mendelian Randomization Study |
| title_full_unstemmed |
Heart Failure and Ischemic Stroke: A Bidirectional and Multivariable Mendelian Randomization Study |
| title_sort |
heart failure and ischemic stroke: a bidirectional and multivariable mendelian randomization study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/e1a0b076acfa4aa8aa54188a541fe7df |
| work_keys_str_mv |
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