Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs

Zearalenone (ZEN) is a mycotoxin classified as an endocrine disruptor. Many endocrine disruptors are also metabolic disruptors able to modulate energy balance and inflammatory processes in a process often involving a family of protein hormones known as adipokines. The aim of our study was to elucida...

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Autores principales:	Veronika Nagl, Bertrand Grenier, Philippe Pinton, Ursula Ruczizka, Maximiliane Dippel, Moritz Bünger, Isabelle P. Oswald, Laura Soler
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mycotoxins zearalenone adipokines metabolism estrogen Medicine R
Acceso en línea:	https://doaj.org/article/e1a7bdb31b414b17a55a5fba8e1eb649
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spelling	oai:doaj.org-article:e1a7bdb31b414b17a55a5fba8e1eb6492021-11-25T19:08:51ZExposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs10.3390/toxins131107902072-6651https://doaj.org/article/e1a7bdb31b414b17a55a5fba8e1eb6492021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6651/13/11/790https://doaj.org/toc/2072-6651Zearalenone (ZEN) is a mycotoxin classified as an endocrine disruptor. Many endocrine disruptors are also metabolic disruptors able to modulate energy balance and inflammatory processes in a process often involving a family of protein hormones known as adipokines. The aim of our study was to elucidate the role of ZEN as metabolic disruptor in pigs by investigating the changes in energy balance and adipokines levels in response to different treatment diets. To this end, weaned piglets (<i>n</i> = 10/group) were exposed to either basal feed or feed contaminated with 680 and 1620 µg/kg ZEN for 28 days. Serum samples collected at days 7 and 21 were subjected to biochemistry analysis, followed by determination of adipokine levels using a combined approach of protein array and ELISA. Results indicate that ZEN has an impact on lipid and glucose metabolism that was different depending on the dose and time of exposure. In agreement with these changes, ZEN altered circulating adipokines concentrations, inducing significant changes in adiponectin, resistin, and fetuin B. Our results suggest that ZEN may function as a natural metabolism-disrupting chemical.Veronika NaglBertrand GrenierPhilippe PintonUrsula RuczizkaMaximiliane DippelMoritz BüngerIsabelle P. OswaldLaura SolerMDPI AGarticlemycotoxinszearalenoneadipokinesmetabolismestrogenMedicineRENToxins, Vol 13, Iss 790, p 790 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mycotoxins zearalenone adipokines metabolism estrogen Medicine R
spellingShingle	mycotoxins zearalenone adipokines metabolism estrogen Medicine R Veronika Nagl Bertrand Grenier Philippe Pinton Ursula Ruczizka Maximiliane Dippel Moritz Bünger Isabelle P. Oswald Laura Soler Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs
description	Zearalenone (ZEN) is a mycotoxin classified as an endocrine disruptor. Many endocrine disruptors are also metabolic disruptors able to modulate energy balance and inflammatory processes in a process often involving a family of protein hormones known as adipokines. The aim of our study was to elucidate the role of ZEN as metabolic disruptor in pigs by investigating the changes in energy balance and adipokines levels in response to different treatment diets. To this end, weaned piglets (<i>n</i> = 10/group) were exposed to either basal feed or feed contaminated with 680 and 1620 µg/kg ZEN for 28 days. Serum samples collected at days 7 and 21 were subjected to biochemistry analysis, followed by determination of adipokine levels using a combined approach of protein array and ELISA. Results indicate that ZEN has an impact on lipid and glucose metabolism that was different depending on the dose and time of exposure. In agreement with these changes, ZEN altered circulating adipokines concentrations, inducing significant changes in adiponectin, resistin, and fetuin B. Our results suggest that ZEN may function as a natural metabolism-disrupting chemical.
format	article
author	Veronika Nagl Bertrand Grenier Philippe Pinton Ursula Ruczizka Maximiliane Dippel Moritz Bünger Isabelle P. Oswald Laura Soler
author_facet	Veronika Nagl Bertrand Grenier Philippe Pinton Ursula Ruczizka Maximiliane Dippel Moritz Bünger Isabelle P. Oswald Laura Soler
author_sort	Veronika Nagl
title	Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs
title_short	Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs
title_full	Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs
title_fullStr	Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs
title_full_unstemmed	Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs
title_sort	exposure to zearalenone leads to metabolic disruption and changes in circulating adipokines concentrations in pigs
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e1a7bdb31b414b17a55a5fba8e1eb649
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Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs

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