Mild obstructive sleep apnea does not modulate baroreflex sensitivity in adult patients
Henry Blomster,1 Tomi P Laitinen,2 Juha EK Hartikainen,3,6 Tiina M Laitinen,2 Esko Vanninen,2 Helena Gylling,4,8 Johanna Sahlman,1 Jouko Kokkarinen,5 Jukka Randell,5 Juha Seppä,1 Henri Tuomilehto4,7 1Department of Otorhinolaryngology, Institute of Clinical Medicine, 2Department of...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2015
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/e1ae627c76514db18594419dfb614e9b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:e1ae627c76514db18594419dfb614e9b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:e1ae627c76514db18594419dfb614e9b2021-12-02T05:03:28ZMild obstructive sleep apnea does not modulate baroreflex sensitivity in adult patients1179-1608https://doaj.org/article/e1ae627c76514db18594419dfb614e9b2015-06-01T00:00:00Zhttp://www.dovepress.com/mild-obstructive-sleep-apnea-does-not-modulate-baroreflex-sensitivity--peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Henry Blomster,1 Tomi P Laitinen,2 Juha EK Hartikainen,3,6 Tiina M Laitinen,2 Esko Vanninen,2 Helena Gylling,4,8 Johanna Sahlman,1 Jouko Kokkarinen,5 Jukka Randell,5 Juha Seppä,1 Henri Tuomilehto4,7 1Department of Otorhinolaryngology, Institute of Clinical Medicine, 2Department of Clinical Physiology and Nuclear Medicine, 3Department of Internal Medicine, 4Department of Clinical Nutrition, School of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 5Department of Respiratory Medicine, 6Heart Center, Kuopio University Hospital, 7Oivauni Sleep Clinic, Kuopio, 8Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland Background: Obstructive sleep apnea (OSA) is a chronic and progressive disease. OSA is associated with increased cardiovascular morbidity and mortality, the risk being more frequently encountered with severe degrees of OSA. Increased sympathetic activation and impaired cardiac autonomic control as reflected by depressed baroreceptor reflex sensitivity (BRS) are possible mechanisms involved in the cardiovascular complications of OSA. However, it is not known at what stage of OSA that changes in BRS appear. The aim of this study was to evaluate BRS in patients with mild OSA. Methods: The study population consisted of 81 overweight patients with mild OSA and 46 body weight-matched non-OSA subjects. BRS, apnea-hypopnea index, body mass index, and metabolic parameters were assessed. The phenylephrine test was used to measure BRS. Results: Patients in the OSA group were slightly but significantly older than the non-OSA population (50.3±9.3 years vs 45.7±11.1 years, P=0.02). Body mass index, percentage body fat, blood pressure, fasting glucose, insulin, and lipid levels did not differ between the OSA patients and non-OSA subjects. Absolute BRS values in patients with mild OSA and non-OSA subjects (9.97±6.70 ms/mmHg vs 10.51±7.16 ms/mmHg, P=0.67) and BRS values proportional to age-related and sex-related reference values (91.4%±22.7% vs 92.2%±21.8%, P=0.84) did not differ from each other. BRS <50% of the sex-specific reference value was found in 6% of patients with mild OSA and in 2% of non-OSA subjects (P=0.29). Conclusion: Patients with mild OSA did not show evidence of disturbed BRS in comparison with weight-matched non-OSA controls. Keywords: obstructive sleep apnea, baroreceptor reflex sensitivityBlomster HLaitinen TPHartikainen JEKLaitinen TMVanninen EGylling HSahlman JKokkarinen JRandell JSeppä JTuomilehto HDove Medical PressarticlePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2015, Iss default, Pp 73-80 (2015) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 |
| spellingShingle |
Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Blomster H Laitinen TP Hartikainen JEK Laitinen TM Vanninen E Gylling H Sahlman J Kokkarinen J Randell J Seppä J Tuomilehto H Mild obstructive sleep apnea does not modulate baroreflex sensitivity in adult patients |
| description |
Henry Blomster,1 Tomi P Laitinen,2 Juha EK Hartikainen,3,6 Tiina M Laitinen,2 Esko Vanninen,2 Helena Gylling,4,8 Johanna Sahlman,1 Jouko Kokkarinen,5 Jukka Randell,5 Juha Seppä,1 Henri Tuomilehto4,7 1Department of Otorhinolaryngology, Institute of Clinical Medicine, 2Department of Clinical Physiology and Nuclear Medicine, 3Department of Internal Medicine, 4Department of Clinical Nutrition, School of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 5Department of Respiratory Medicine, 6Heart Center, Kuopio University Hospital, 7Oivauni Sleep Clinic, Kuopio, 8Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland Background: Obstructive sleep apnea (OSA) is a chronic and progressive disease. OSA is associated with increased cardiovascular morbidity and mortality, the risk being more frequently encountered with severe degrees of OSA. Increased sympathetic activation and impaired cardiac autonomic control as reflected by depressed baroreceptor reflex sensitivity (BRS) are possible mechanisms involved in the cardiovascular complications of OSA. However, it is not known at what stage of OSA that changes in BRS appear. The aim of this study was to evaluate BRS in patients with mild OSA. Methods: The study population consisted of 81 overweight patients with mild OSA and 46 body weight-matched non-OSA subjects. BRS, apnea-hypopnea index, body mass index, and metabolic parameters were assessed. The phenylephrine test was used to measure BRS. Results: Patients in the OSA group were slightly but significantly older than the non-OSA population (50.3±9.3 years vs 45.7±11.1 years, P=0.02). Body mass index, percentage body fat, blood pressure, fasting glucose, insulin, and lipid levels did not differ between the OSA patients and non-OSA subjects. Absolute BRS values in patients with mild OSA and non-OSA subjects (9.97±6.70 ms/mmHg vs 10.51±7.16 ms/mmHg, P=0.67) and BRS values proportional to age-related and sex-related reference values (91.4%±22.7% vs 92.2%±21.8%, P=0.84) did not differ from each other. BRS <50% of the sex-specific reference value was found in 6% of patients with mild OSA and in 2% of non-OSA subjects (P=0.29). Conclusion: Patients with mild OSA did not show evidence of disturbed BRS in comparison with weight-matched non-OSA controls. Keywords: obstructive sleep apnea, baroreceptor reflex sensitivity |
| format |
article |
| author |
Blomster H Laitinen TP Hartikainen JEK Laitinen TM Vanninen E Gylling H Sahlman J Kokkarinen J Randell J Seppä J Tuomilehto H |
| author_facet |
Blomster H Laitinen TP Hartikainen JEK Laitinen TM Vanninen E Gylling H Sahlman J Kokkarinen J Randell J Seppä J Tuomilehto H |
| author_sort |
Blomster H |
| title |
Mild obstructive sleep apnea does not modulate baroreflex sensitivity in adult patients |
| title_short |
Mild obstructive sleep apnea does not modulate baroreflex sensitivity in adult patients |
| title_full |
Mild obstructive sleep apnea does not modulate baroreflex sensitivity in adult patients |
| title_fullStr |
Mild obstructive sleep apnea does not modulate baroreflex sensitivity in adult patients |
| title_full_unstemmed |
Mild obstructive sleep apnea does not modulate baroreflex sensitivity in adult patients |
| title_sort |
mild obstructive sleep apnea does not modulate baroreflex sensitivity in adult patients |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/e1ae627c76514db18594419dfb614e9b |
| work_keys_str_mv |
AT blomsterh mildobstructivesleepapneadoesnotmodulatebaroreflexsensitivityinadultpatients AT laitinentp mildobstructivesleepapneadoesnotmodulatebaroreflexsensitivityinadultpatients AT hartikainenjek mildobstructivesleepapneadoesnotmodulatebaroreflexsensitivityinadultpatients AT laitinentm mildobstructivesleepapneadoesnotmodulatebaroreflexsensitivityinadultpatients AT vanninene mildobstructivesleepapneadoesnotmodulatebaroreflexsensitivityinadultpatients AT gyllingh mildobstructivesleepapneadoesnotmodulatebaroreflexsensitivityinadultpatients AT sahlmanj mildobstructivesleepapneadoesnotmodulatebaroreflexsensitivityinadultpatients AT kokkarinenj mildobstructivesleepapneadoesnotmodulatebaroreflexsensitivityinadultpatients AT randellj mildobstructivesleepapneadoesnotmodulatebaroreflexsensitivityinadultpatients AT seppaj mildobstructivesleepapneadoesnotmodulatebaroreflexsensitivityinadultpatients AT tuomilehtoh mildobstructivesleepapneadoesnotmodulatebaroreflexsensitivityinadultpatients |
| _version_ |
1718400743116898304 |