Combined Photothermotherapy and Chemotherapy of Oral Squamous Cell Carcinoma Guided by Multifunctional Nanomaterials Enhanced Photoacoustic Tomography

Sujuan Zeng,1,&ast; Shiqi Liu,1,2,&ast; Yintao Lan,3 Ting Qiu,3 Mengyu Zhou,3 Weijian Gao,3 Wenyan Huang,1 Lihong Ge,1,4 Jian Zhang1,3 1Department of Pedodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Key Laboratory of Basic and Applied Research of Oral R...

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Autores principales:	Zeng S, Liu S, Lan Y, Qiu T, Zhou M, Gao W, Huang W, Ge L, Zhang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	mesoporous silica coated gold nanorods photoacoustic imaging chemo-photothermal therapy oral squamous cell carcinoma Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e1b10457a1d9403782886e579d3c48db
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spelling	oai:doaj.org-article:e1b10457a1d9403782886e579d3c48db2021-12-02T17:54:55ZCombined Photothermotherapy and Chemotherapy of Oral Squamous Cell Carcinoma Guided by Multifunctional Nanomaterials Enhanced Photoacoustic Tomography1178-2013https://doaj.org/article/e1b10457a1d9403782886e579d3c48db2021-11-01T00:00:00Zhttps://www.dovepress.com/combined-photothermotherapy-and-chemotherapy-of-oral-squamous-cell-car-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Sujuan Zeng,1,&ast; Shiqi Liu,1,2,&ast; Yintao Lan,3 Ting Qiu,3 Mengyu Zhou,3 Weijian Gao,3 Wenyan Huang,1 Lihong Ge,1,4 Jian Zhang1,3 1Department of Pedodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong, People’s Republic of China; 2Department of Stomatology, Taihe Hospital, Institute of Oral Diseases, School of Dentistry, Hubei University of Medicine, Hubei, People’s Republic of China; 3Department of Biomedical Engineering, School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Guangzhou Medical University, Guangdong, People’s Republic of China; 4Department of Pediatric Dentistry, Stomatology Hospital of Peking University, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jian Zhang; Lihong Ge Email jianzhang@gzhmu.edu.cn; gelh0919@126.comBackground: Squamous cell carcinoma of the head and neck is the sixth most common cancer worldwide, with 40% occurring in the oral cavity. Although the level of early diagnosis and treatment of OSCC has improved significantly, the five-year survival rate of advanced patients remains unsatisfactory. However, the main challenges before us are how to get an early and accurate diagnosis and how to formulate effective treatment. Nanoparticle-based chemo-photothermal therapy has proven to be a promising non-invasive approach to treating oral squamous cell carcinoma treatment.Methods: In this study, we tried to design and synthesize multifunctional hyaluronic acid (HA) modified gold nanorods/mesoporous silica-based nanoparticles loaded with doxorubicin hydrochloride (DOX) for photoacoustic imaging (PAI) guided cooperative chemo-photothermal therapy.Results: The resultant nanocomposite shows favorable biocompatibility, relatively low cytotoxicity, ideal drug loading capability and strong PAI signals. In addition, they showed an excellent photothermal conversion efficiency of 49.02% for photothermal therapy (PTT). Moreover, in vivo and in vitro experiments have shown that synergistic chemo-photothermal therapy has better therapeutic effects than chemotherapy alone or PTT (P < 0.05). After being injected into the CAL-27 tumor-bearing mice, the DOX-AuNRs@mSiO2-HA nanoparticles could accumulate rapidly at the tumor sites and achieve complete ablation of tumors when combined with near-infrared laser irradiation, without obvious side effects on normal tissues.Conclusion: Our research provides a solid demonstration of the potential of DOX–AuNRs@mSiO2-HA as a multifunctional platform in PAI-guided photothermal chemotherapy for oral squamous cell carcinoma.Keywords: mesoporous silica coated gold nanorods, photoacoustic imaging, chemo-photothermal therapy, oral squamous cell carcinomaZeng SLiu SLan YQiu TZhou MGao WHuang WGe LZhang JDove Medical Pressarticlemesoporous silica coated gold nanorodsphotoacoustic imagingchemo-photothermal therapyoral squamous cell carcinomaMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 7373-7390 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesoporous silica coated gold nanorods photoacoustic imaging chemo-photothermal therapy oral squamous cell carcinoma Medicine (General) R5-920
spellingShingle	mesoporous silica coated gold nanorods photoacoustic imaging chemo-photothermal therapy oral squamous cell carcinoma Medicine (General) R5-920 Zeng S Liu S Lan Y Qiu T Zhou M Gao W Huang W Ge L Zhang J Combined Photothermotherapy and Chemotherapy of Oral Squamous Cell Carcinoma Guided by Multifunctional Nanomaterials Enhanced Photoacoustic Tomography
description	Sujuan Zeng,1,&ast; Shiqi Liu,1,2,&ast; Yintao Lan,3 Ting Qiu,3 Mengyu Zhou,3 Weijian Gao,3 Wenyan Huang,1 Lihong Ge,1,4 Jian Zhang1,3 1Department of Pedodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong, People’s Republic of China; 2Department of Stomatology, Taihe Hospital, Institute of Oral Diseases, School of Dentistry, Hubei University of Medicine, Hubei, People’s Republic of China; 3Department of Biomedical Engineering, School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Guangzhou Medical University, Guangdong, People’s Republic of China; 4Department of Pediatric Dentistry, Stomatology Hospital of Peking University, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jian Zhang; Lihong Ge Email jianzhang@gzhmu.edu.cn; gelh0919@126.comBackground: Squamous cell carcinoma of the head and neck is the sixth most common cancer worldwide, with 40% occurring in the oral cavity. Although the level of early diagnosis and treatment of OSCC has improved significantly, the five-year survival rate of advanced patients remains unsatisfactory. However, the main challenges before us are how to get an early and accurate diagnosis and how to formulate effective treatment. Nanoparticle-based chemo-photothermal therapy has proven to be a promising non-invasive approach to treating oral squamous cell carcinoma treatment.Methods: In this study, we tried to design and synthesize multifunctional hyaluronic acid (HA) modified gold nanorods/mesoporous silica-based nanoparticles loaded with doxorubicin hydrochloride (DOX) for photoacoustic imaging (PAI) guided cooperative chemo-photothermal therapy.Results: The resultant nanocomposite shows favorable biocompatibility, relatively low cytotoxicity, ideal drug loading capability and strong PAI signals. In addition, they showed an excellent photothermal conversion efficiency of 49.02% for photothermal therapy (PTT). Moreover, in vivo and in vitro experiments have shown that synergistic chemo-photothermal therapy has better therapeutic effects than chemotherapy alone or PTT (P < 0.05). After being injected into the CAL-27 tumor-bearing mice, the DOX-AuNRs@mSiO2-HA nanoparticles could accumulate rapidly at the tumor sites and achieve complete ablation of tumors when combined with near-infrared laser irradiation, without obvious side effects on normal tissues.Conclusion: Our research provides a solid demonstration of the potential of DOX–AuNRs@mSiO2-HA as a multifunctional platform in PAI-guided photothermal chemotherapy for oral squamous cell carcinoma.Keywords: mesoporous silica coated gold nanorods, photoacoustic imaging, chemo-photothermal therapy, oral squamous cell carcinoma
format	article
author	Zeng S Liu S Lan Y Qiu T Zhou M Gao W Huang W Ge L Zhang J
author_facet	Zeng S Liu S Lan Y Qiu T Zhou M Gao W Huang W Ge L Zhang J
author_sort	Zeng S
title	Combined Photothermotherapy and Chemotherapy of Oral Squamous Cell Carcinoma Guided by Multifunctional Nanomaterials Enhanced Photoacoustic Tomography
title_short	Combined Photothermotherapy and Chemotherapy of Oral Squamous Cell Carcinoma Guided by Multifunctional Nanomaterials Enhanced Photoacoustic Tomography
title_full	Combined Photothermotherapy and Chemotherapy of Oral Squamous Cell Carcinoma Guided by Multifunctional Nanomaterials Enhanced Photoacoustic Tomography
title_fullStr	Combined Photothermotherapy and Chemotherapy of Oral Squamous Cell Carcinoma Guided by Multifunctional Nanomaterials Enhanced Photoacoustic Tomography
title_full_unstemmed	Combined Photothermotherapy and Chemotherapy of Oral Squamous Cell Carcinoma Guided by Multifunctional Nanomaterials Enhanced Photoacoustic Tomography
title_sort	combined photothermotherapy and chemotherapy of oral squamous cell carcinoma guided by multifunctional nanomaterials enhanced photoacoustic tomography
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e1b10457a1d9403782886e579d3c48db
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Combined Photothermotherapy and Chemotherapy of Oral Squamous Cell Carcinoma Guided by Multifunctional Nanomaterials Enhanced Photoacoustic Tomography

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