TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone

Parathyroid hormone (PTH) is used to treat osteoporosis, but its therapeutic mechanism remains unclear. Here, the authors show that Tgif1 is a PTH target gene, and that its deletion impairs the function of osteoblasts and PTH-induced bone formation in mice.

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Autores principales:	Hiroaki Saito, Andreas Gasser, Simona Bolamperti, Miki Maeda, Levi Matthies, Katharina Jähn, Courtney L. Long, Hartmut Schlüter, Marcel Kwiatkowski, Vaibhav Saini, Paola Divieti Pajevic, Teresita Bellido, Andre J. van Wijnen, Khalid S. Mohammad, Theresa A. Guise, Hanna Taipaleenmäki, Eric Hesse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e1b46a452798403ebde7a78a57d3c849
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spelling	oai:doaj.org-article:e1b46a452798403ebde7a78a57d3c8492021-12-02T17:33:23ZTG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone10.1038/s41467-019-08778-x2041-1723https://doaj.org/article/e1b46a452798403ebde7a78a57d3c8492019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08778-xhttps://doaj.org/toc/2041-1723Parathyroid hormone (PTH) is used to treat osteoporosis, but its therapeutic mechanism remains unclear. Here, the authors show that Tgif1 is a PTH target gene, and that its deletion impairs the function of osteoblasts and PTH-induced bone formation in mice.Hiroaki SaitoAndreas GasserSimona BolampertiMiki MaedaLevi MatthiesKatharina JähnCourtney L. LongHartmut SchlüterMarcel KwiatkowskiVaibhav SainiPaola Divieti PajevicTeresita BellidoAndre J. van WijnenKhalid S. MohammadTheresa A. GuiseHanna TaipaleenmäkiEric HesseNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroaki Saito Andreas Gasser Simona Bolamperti Miki Maeda Levi Matthies Katharina Jähn Courtney L. Long Hartmut Schlüter Marcel Kwiatkowski Vaibhav Saini Paola Divieti Pajevic Teresita Bellido Andre J. van Wijnen Khalid S. Mohammad Theresa A. Guise Hanna Taipaleenmäki Eric Hesse TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
description	Parathyroid hormone (PTH) is used to treat osteoporosis, but its therapeutic mechanism remains unclear. Here, the authors show that Tgif1 is a PTH target gene, and that its deletion impairs the function of osteoblasts and PTH-induced bone formation in mice.
format	article
author	Hiroaki Saito Andreas Gasser Simona Bolamperti Miki Maeda Levi Matthies Katharina Jähn Courtney L. Long Hartmut Schlüter Marcel Kwiatkowski Vaibhav Saini Paola Divieti Pajevic Teresita Bellido Andre J. van Wijnen Khalid S. Mohammad Theresa A. Guise Hanna Taipaleenmäki Eric Hesse
author_facet	Hiroaki Saito Andreas Gasser Simona Bolamperti Miki Maeda Levi Matthies Katharina Jähn Courtney L. Long Hartmut Schlüter Marcel Kwiatkowski Vaibhav Saini Paola Divieti Pajevic Teresita Bellido Andre J. van Wijnen Khalid S. Mohammad Theresa A. Guise Hanna Taipaleenmäki Eric Hesse
author_sort	Hiroaki Saito
title	TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
title_short	TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
title_full	TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
title_fullStr	TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
title_full_unstemmed	TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
title_sort	tg-interacting factor 1 (tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e1b46a452798403ebde7a78a57d3c849
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TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone

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