The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis

Abstract Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue disease (CTD), causing death in systemic sclerosis (SSc). The past decade has yielded many scientific insights into microRNA (miRNAs) in PAH and SSc. This growth of knowledge has well-illustrated the complex...

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Autores principales:	Bei Xu, Guanhua Xu, Ye Yu, Jin Lin
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Pulmonary arterial hypertension miRNAs Systemic sclerosis Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/e1b6198ac4f14b6e880de5d722b50229
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spelling	oai:doaj.org-article:e1b6198ac4f14b6e880de5d722b502292021-11-28T12:04:49ZThe role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis10.1186/s13075-021-02678-61478-6362https://doaj.org/article/e1b6198ac4f14b6e880de5d722b502292021-11-01T00:00:00Zhttps://doi.org/10.1186/s13075-021-02678-6https://doaj.org/toc/1478-6362Abstract Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue disease (CTD), causing death in systemic sclerosis (SSc). The past decade has yielded many scientific insights into microRNA (miRNAs) in PAH and SSc. This growth of knowledge has well-illustrated the complexity of microRNA (miRNA)-based regulation of gene expression in PAH. However, few miRNA-related SSc-PAH were elucidated. This review firstly discusses the role of transforming growth factor-beta (TGF-β) signaling and bone morphogenetic protein receptor type II (BMPR2) in PAH and SSc. Secondly, the miRNAs relating to TGF-β and BMPR2 signaling pathways in PAH and SSc or merely PAH were subsequently summarized. Finally, future studies might develop early diagnostic biomarkers and target-oriented therapeutic strategies for SSc-PAH and PAH treatment.Bei XuGuanhua XuYe YuJin LinBMCarticlePulmonary arterial hypertensionmiRNAsSystemic sclerosisDiseases of the musculoskeletal systemRC925-935ENArthritis Research & Therapy, Vol 23, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pulmonary arterial hypertension miRNAs Systemic sclerosis Diseases of the musculoskeletal system RC925-935
spellingShingle	Pulmonary arterial hypertension miRNAs Systemic sclerosis Diseases of the musculoskeletal system RC925-935 Bei Xu Guanhua Xu Ye Yu Jin Lin The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis
description	Abstract Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue disease (CTD), causing death in systemic sclerosis (SSc). The past decade has yielded many scientific insights into microRNA (miRNAs) in PAH and SSc. This growth of knowledge has well-illustrated the complexity of microRNA (miRNA)-based regulation of gene expression in PAH. However, few miRNA-related SSc-PAH were elucidated. This review firstly discusses the role of transforming growth factor-beta (TGF-β) signaling and bone morphogenetic protein receptor type II (BMPR2) in PAH and SSc. Secondly, the miRNAs relating to TGF-β and BMPR2 signaling pathways in PAH and SSc or merely PAH were subsequently summarized. Finally, future studies might develop early diagnostic biomarkers and target-oriented therapeutic strategies for SSc-PAH and PAH treatment.
format	article
author	Bei Xu Guanhua Xu Ye Yu Jin Lin
author_facet	Bei Xu Guanhua Xu Ye Yu Jin Lin
author_sort	Bei Xu
title	The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis
title_short	The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis
title_full	The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis
title_fullStr	The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis
title_full_unstemmed	The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis
title_sort	role of tgf-β or bmpr2 signaling pathway-related mirna in pulmonary arterial hypertension and systemic sclerosis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e1b6198ac4f14b6e880de5d722b50229
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The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis

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