POEMS- A Diagnostic Odyssey

POEMS syndrome is a rare multisystem paraneoplastic disease that manifests with a spectrum of symptoms namely peripheral neuropathy (P), organomegaly (O), endocrinopathy (E) monoclonal plasma-cells proliferative disorder (M) and skin changes (S). This case report presents an elderly lady who present...

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Autores principales:	Cynthia Amrutha Sukumar, Sumanth Madan, Shipra Rai, Kavitha Saravu
Formato:	article
Lenguaje:	EN
Publicado:	Light House Polyclinic Mangalore 2021
Materias:	poems paraneoplastic syndromes gitelman-like syndrome myeloma peripheral neuropathy Medicine R
Acceso en línea:	https://doaj.org/article/e1bd39bd671c48f18d2c594294a6aea6
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spelling	oai:doaj.org-article:e1bd39bd671c48f18d2c594294a6aea62021-11-12T09:13:28ZPOEMS- A Diagnostic Odyssey0972-5997https://doaj.org/article/e1bd39bd671c48f18d2c594294a6aea62021-10-01T00:00:00Zhttps://www.ojhas.org/issue79/2021-3-16.htmlhttps://doaj.org/toc/0972-5997POEMS syndrome is a rare multisystem paraneoplastic disease that manifests with a spectrum of symptoms namely peripheral neuropathy (P), organomegaly (O), endocrinopathy (E) monoclonal plasma-cells proliferative disorder (M) and skin changes (S). This case report presents an elderly lady who presented with unexplained quadriparesis. Nerve conduction studies suggested peripheral neuropathy. Atypical lymphocytes on the peripheral smear led to the suspicion of a hematological malignancy with peripheral neuropathy presenting as a paraneoplastic syndrome. Bone marrow biopsy confirmed the diagnosis of plasma cell myeloma. The combined presence of myeloma with peripheral neuropathy led to the consideration of POEMS syndrome. This patient also presented with an unexplained persistent hypokalemia with metabolic alkalosis with normal renal function tests and thus, a Gitelman like syndrome was considered. This case report accentuates the plethora of symptoms that characterize POEMS and also highlights the extremely rare association of acquired Gitelman-like syndrome with POEMS syndrome.Cynthia Amrutha SukumarSumanth MadanShipra RaiKavitha SaravuLight House Polyclinic Mangalore articlepoemsparaneoplastic syndromesgitelman-like syndromemyelomaperipheral neuropathyMedicineRENOnline Journal of Health & Allied Sciences, Vol 20, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	poems paraneoplastic syndromes gitelman-like syndrome myeloma peripheral neuropathy Medicine R
spellingShingle	poems paraneoplastic syndromes gitelman-like syndrome myeloma peripheral neuropathy Medicine R Cynthia Amrutha Sukumar Sumanth Madan Shipra Rai Kavitha Saravu POEMS- A Diagnostic Odyssey
description	POEMS syndrome is a rare multisystem paraneoplastic disease that manifests with a spectrum of symptoms namely peripheral neuropathy (P), organomegaly (O), endocrinopathy (E) monoclonal plasma-cells proliferative disorder (M) and skin changes (S). This case report presents an elderly lady who presented with unexplained quadriparesis. Nerve conduction studies suggested peripheral neuropathy. Atypical lymphocytes on the peripheral smear led to the suspicion of a hematological malignancy with peripheral neuropathy presenting as a paraneoplastic syndrome. Bone marrow biopsy confirmed the diagnosis of plasma cell myeloma. The combined presence of myeloma with peripheral neuropathy led to the consideration of POEMS syndrome. This patient also presented with an unexplained persistent hypokalemia with metabolic alkalosis with normal renal function tests and thus, a Gitelman like syndrome was considered. This case report accentuates the plethora of symptoms that characterize POEMS and also highlights the extremely rare association of acquired Gitelman-like syndrome with POEMS syndrome.
format	article
author	Cynthia Amrutha Sukumar Sumanth Madan Shipra Rai Kavitha Saravu
author_facet	Cynthia Amrutha Sukumar Sumanth Madan Shipra Rai Kavitha Saravu
author_sort	Cynthia Amrutha Sukumar
title	POEMS- A Diagnostic Odyssey
title_short	POEMS- A Diagnostic Odyssey
title_full	POEMS- A Diagnostic Odyssey
title_fullStr	POEMS- A Diagnostic Odyssey
title_full_unstemmed	POEMS- A Diagnostic Odyssey
title_sort	poems- a diagnostic odyssey
publisher	Light House Polyclinic Mangalore
publishDate	2021
url	https://doaj.org/article/e1bd39bd671c48f18d2c594294a6aea6
work_keys_str_mv	AT cynthiaamruthasukumar poemsadiagnosticodyssey AT sumanthmadan poemsadiagnosticodyssey AT shiprarai poemsadiagnosticodyssey AT kavithasaravu poemsadiagnosticodyssey
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POEMS- A Diagnostic Odyssey

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