Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene.
<h4>Background</h4>Coronary restenosis after percutaneous coronary intervention (PCI) still remains a significant limitation of the procedure. The causative mechanisms of restenosis have not yet been fully identified. The goal of the current study was to perform gene-set analysis of biol...
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oai:doaj.org-article:e1c0920721814b3087ab0fc56b703b7c2021-11-18T09:00:29ZPathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene.1932-620310.1371/journal.pone.0070676https://doaj.org/article/e1c0920721814b3087ab0fc56b703b7c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23950981/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Coronary restenosis after percutaneous coronary intervention (PCI) still remains a significant limitation of the procedure. The causative mechanisms of restenosis have not yet been fully identified. The goal of the current study was to perform gene-set analysis of biological pathways related to inflammation, proliferation, vascular function and transcriptional regulation on coronary restenosis to identify novel genes and pathways related to this condition.<h4>Methods</h4>The GENetic DEterminants of Restenosis (GENDER) databank contains genotypic data of 556,099SNPs of 295 cases with restenosis and 571 matched controls. Fifty-four pathways, related to known restenosis-related processes, were selected. Gene-set analysis was performed using PLINK, GRASS and ALIGATOR software. Pathways with a p<0.01 were fine-mapped and significantly associated SNPs were analyzed in an independent replication cohort.<h4>Results</h4>Six pathways (cell-extracellular matrix (ECM) interactions pathway, IL2 signaling pathway, IL6 signaling pathway, platelet derived growth factor pathway, vitamin D receptor pathway and the mitochondria pathway) were significantly associated in one or two of the software packages. Two SNPs in the cell-ECM interactions pathway were replicated in an independent restenosis cohort. No replication was obtained for the other pathways.<h4>Conclusion</h4>With these results we demonstrate a potential role of the cell-ECM interactions pathway in the development of coronary restenosis. These findings contribute to the increasing knowledge of the genetic etiology of restenosis formation and could serve as a hypothesis-generating effort for further functional studies.Jeffrey J W VerschurenStella TrompetM Lourdes SampietroBastiaan T HeijmansWerner KochAdnan KastratiJeanine J Houwing-DuistermaatP Eline SlagboomPaul H A QuaxJ Wouter JukemaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e70676 (2013) |
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Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Jeffrey J W Verschuren Stella Trompet M Lourdes Sampietro Bastiaan T Heijmans Werner Koch Adnan Kastrati Jeanine J Houwing-Duistermaat P Eline Slagboom Paul H A Quax J Wouter Jukema Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene. |
| description |
<h4>Background</h4>Coronary restenosis after percutaneous coronary intervention (PCI) still remains a significant limitation of the procedure. The causative mechanisms of restenosis have not yet been fully identified. The goal of the current study was to perform gene-set analysis of biological pathways related to inflammation, proliferation, vascular function and transcriptional regulation on coronary restenosis to identify novel genes and pathways related to this condition.<h4>Methods</h4>The GENetic DEterminants of Restenosis (GENDER) databank contains genotypic data of 556,099SNPs of 295 cases with restenosis and 571 matched controls. Fifty-four pathways, related to known restenosis-related processes, were selected. Gene-set analysis was performed using PLINK, GRASS and ALIGATOR software. Pathways with a p<0.01 were fine-mapped and significantly associated SNPs were analyzed in an independent replication cohort.<h4>Results</h4>Six pathways (cell-extracellular matrix (ECM) interactions pathway, IL2 signaling pathway, IL6 signaling pathway, platelet derived growth factor pathway, vitamin D receptor pathway and the mitochondria pathway) were significantly associated in one or two of the software packages. Two SNPs in the cell-ECM interactions pathway were replicated in an independent restenosis cohort. No replication was obtained for the other pathways.<h4>Conclusion</h4>With these results we demonstrate a potential role of the cell-ECM interactions pathway in the development of coronary restenosis. These findings contribute to the increasing knowledge of the genetic etiology of restenosis formation and could serve as a hypothesis-generating effort for further functional studies. |
| format |
article |
| author |
Jeffrey J W Verschuren Stella Trompet M Lourdes Sampietro Bastiaan T Heijmans Werner Koch Adnan Kastrati Jeanine J Houwing-Duistermaat P Eline Slagboom Paul H A Quax J Wouter Jukema |
| author_facet |
Jeffrey J W Verschuren Stella Trompet M Lourdes Sampietro Bastiaan T Heijmans Werner Koch Adnan Kastrati Jeanine J Houwing-Duistermaat P Eline Slagboom Paul H A Quax J Wouter Jukema |
| author_sort |
Jeffrey J W Verschuren |
| title |
Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene. |
| title_short |
Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene. |
| title_full |
Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene. |
| title_fullStr |
Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene. |
| title_full_unstemmed |
Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene. |
| title_sort |
pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the parvb gene. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/e1c0920721814b3087ab0fc56b703b7c |
| work_keys_str_mv |
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