Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging

Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging

Epigenetic silencing of Lgr5 in aged organoids To understand the molecular features underlying stem cell aging, we established intestinal epithelial organoids derived from both young and aged mice, and investigated alterations in their senescence and epigenetic status. Senescence-related changes inc...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ryoei Uchida, Yoshimasa Saito, Kazuki Nogami, Yohei Kajiyama, Yukana Suzuki, Yasuhiro Kawase, Toshiaki Nakaoka, Toshihide Muramatsu, Masaki Kimura, Hidetsugu Saito
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/e1c53da2776440f3a69b4e2f9cf4edf3
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares