Targeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer

Silvia Liu et al. present LoopSeq, a synthetic long-read sequencing method that generates accurate long-read transcriptome data from short Illumina reads. As an example of possible applications, they use LoopSeq to investigate differential isoform expression, isoform-specific single nucleotide varia...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Silvia Liu, Indira Wu, Yan-Ping Yu, Michael Balamotis, Baoguo Ren, Tuval Ben Yehezkel, Jian-Hua Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e1cb04e6a8a1480383f9180ac1ea8876
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e1cb04e6a8a1480383f9180ac1ea8876
record_format	dspace
spelling	oai:doaj.org-article:e1cb04e6a8a1480383f9180ac1ea88762021-12-02T17:15:15ZTargeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer10.1038/s42003-021-02024-12399-3642https://doaj.org/article/e1cb04e6a8a1480383f9180ac1ea88762021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02024-1https://doaj.org/toc/2399-3642Silvia Liu et al. present LoopSeq, a synthetic long-read sequencing method that generates accurate long-read transcriptome data from short Illumina reads. As an example of possible applications, they use LoopSeq to investigate differential isoform expression, isoform-specific single nucleotide variants, and potential fusion genes in multiple stages of colon cancer. Altogether, LoopSeq is a valuable method for analyzing complex transcriptomes and investigating gene expression at the isoform level.Silvia LiuIndira WuYan-Ping YuMichael BalamotisBaoguo RenTuval Ben YehezkelJian-Hua LuoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Silvia Liu Indira Wu Yan-Ping Yu Michael Balamotis Baoguo Ren Tuval Ben Yehezkel Jian-Hua Luo Targeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer
description	Silvia Liu et al. present LoopSeq, a synthetic long-read sequencing method that generates accurate long-read transcriptome data from short Illumina reads. As an example of possible applications, they use LoopSeq to investigate differential isoform expression, isoform-specific single nucleotide variants, and potential fusion genes in multiple stages of colon cancer. Altogether, LoopSeq is a valuable method for analyzing complex transcriptomes and investigating gene expression at the isoform level.
format	article
author	Silvia Liu Indira Wu Yan-Ping Yu Michael Balamotis Baoguo Ren Tuval Ben Yehezkel Jian-Hua Luo
author_facet	Silvia Liu Indira Wu Yan-Ping Yu Michael Balamotis Baoguo Ren Tuval Ben Yehezkel Jian-Hua Luo
author_sort	Silvia Liu
title	Targeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer
title_short	Targeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer
title_full	Targeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer
title_fullStr	Targeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer
title_full_unstemmed	Targeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer
title_sort	targeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e1cb04e6a8a1480383f9180ac1ea8876
work_keys_str_mv	AT silvialiu targetedtranscriptomeanalysisusingsyntheticlongreadsequencinguncoversisoformreprogramingintheprogressionofcoloncancer AT indirawu targetedtranscriptomeanalysisusingsyntheticlongreadsequencinguncoversisoformreprogramingintheprogressionofcoloncancer AT yanpingyu targetedtranscriptomeanalysisusingsyntheticlongreadsequencinguncoversisoformreprogramingintheprogressionofcoloncancer AT michaelbalamotis targetedtranscriptomeanalysisusingsyntheticlongreadsequencinguncoversisoformreprogramingintheprogressionofcoloncancer AT baoguoren targetedtranscriptomeanalysisusingsyntheticlongreadsequencinguncoversisoformreprogramingintheprogressionofcoloncancer AT tuvalbenyehezkel targetedtranscriptomeanalysisusingsyntheticlongreadsequencinguncoversisoformreprogramingintheprogressionofcoloncancer AT jianhualuo targetedtranscriptomeanalysisusingsyntheticlongreadsequencinguncoversisoformreprogramingintheprogressionofcoloncancer
_version_	1718381292885639168

Targeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer

Ejemplares similares