Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain

Myelin formation is regulated by epigenetic mechanisms and ensures proper neuronal function during development and after demyelination. Here, the authors show that TET1, a DNA hydroxymethylase, regulates myelination during development and remyelination in mice.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ming Zhang, Jian Wang, Kaixiang Zhang, Guozhen Lu, Yuming Liu, Keke Ren, Wenting Wang, Dazhuan Xin, Lingli Xu, Honghui Mao, Junlin Xing, Xingchun Gao, Weilin Jin, Kalen Berry, Katsuhiko Mikoshiba, Shengxi Wu, Q. Richard Lu, Xianghui Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e1cbd11d253c49be9a1549ae252b0873
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e1cbd11d253c49be9a1549ae252b0873
record_format	dspace
spelling	oai:doaj.org-article:e1cbd11d253c49be9a1549ae252b08732021-12-02T18:53:15ZTen-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain10.1038/s41467-021-25353-52041-1723https://doaj.org/article/e1cbd11d253c49be9a1549ae252b08732021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25353-5https://doaj.org/toc/2041-1723Myelin formation is regulated by epigenetic mechanisms and ensures proper neuronal function during development and after demyelination. Here, the authors show that TET1, a DNA hydroxymethylase, regulates myelination during development and remyelination in mice.Ming ZhangJian WangKaixiang ZhangGuozhen LuYuming LiuKeke RenWenting WangDazhuan XinLingli XuHonghui MaoJunlin XingXingchun GaoWeilin JinKalen BerryKatsuhiko MikoshibaShengxi WuQ. Richard LuXianghui ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ming Zhang Jian Wang Kaixiang Zhang Guozhen Lu Yuming Liu Keke Ren Wenting Wang Dazhuan Xin Lingli Xu Honghui Mao Junlin Xing Xingchun Gao Weilin Jin Kalen Berry Katsuhiko Mikoshiba Shengxi Wu Q. Richard Lu Xianghui Zhao Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain
description	Myelin formation is regulated by epigenetic mechanisms and ensures proper neuronal function during development and after demyelination. Here, the authors show that TET1, a DNA hydroxymethylase, regulates myelination during development and remyelination in mice.
format	article
author	Ming Zhang Jian Wang Kaixiang Zhang Guozhen Lu Yuming Liu Keke Ren Wenting Wang Dazhuan Xin Lingli Xu Honghui Mao Junlin Xing Xingchun Gao Weilin Jin Kalen Berry Katsuhiko Mikoshiba Shengxi Wu Q. Richard Lu Xianghui Zhao
author_facet	Ming Zhang Jian Wang Kaixiang Zhang Guozhen Lu Yuming Liu Keke Ren Wenting Wang Dazhuan Xin Lingli Xu Honghui Mao Junlin Xing Xingchun Gao Weilin Jin Kalen Berry Katsuhiko Mikoshiba Shengxi Wu Q. Richard Lu Xianghui Zhao
author_sort	Ming Zhang
title	Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain
title_short	Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain
title_full	Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain
title_fullStr	Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain
title_full_unstemmed	Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain
title_sort	ten-eleven translocation 1 mediated-dna hydroxymethylation is required for myelination and remyelination in the mouse brain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e1cbd11d253c49be9a1549ae252b0873
work_keys_str_mv	AT mingzhang teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT jianwang teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT kaixiangzhang teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT guozhenlu teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT yumingliu teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT kekeren teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT wentingwang teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT dazhuanxin teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT linglixu teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT honghuimao teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT junlinxing teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT xingchungao teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT weilinjin teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT kalenberry teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT katsuhikomikoshiba teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT shengxiwu teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT qrichardlu teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain AT xianghuizhao teneleventranslocation1mediateddnahydroxymethylationisrequiredformyelinationandremyelinationinthemousebrain
_version_	1718377358770044928

Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain

Ejemplares similares