Genetically determined hypoalbuminemia as a risk factor for hypertension: instrumental variable analysis

Abstract Hypoalbuminemia is associated with vascular endothelial dysfunction and the development of chronic cardiovascular diseases. However, the relationship between serum albumin concentration and blood pressure changes remains controversial. Community-based longitudinal cohort data collected from...

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Autores principales:	Jong Wook Choi, Joon-Sung Park, Chang Hwa Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e1cd63fe9f8242488f199fb3e4859f02
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spelling	oai:doaj.org-article:e1cd63fe9f8242488f199fb3e4859f022021-12-02T14:49:17ZGenetically determined hypoalbuminemia as a risk factor for hypertension: instrumental variable analysis10.1038/s41598-021-89775-32045-2322https://doaj.org/article/e1cd63fe9f8242488f199fb3e4859f022021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89775-3https://doaj.org/toc/2045-2322Abstract Hypoalbuminemia is associated with vascular endothelial dysfunction and the development of chronic cardiovascular diseases. However, the relationship between serum albumin concentration and blood pressure changes remains controversial. Community-based longitudinal cohort data collected from Korean Genome and Epidemiology Study were used in this study. Hypoalbuminemia was defined as a serum albumin concentration of ≤ 4.0 g/dL. A total of 4325 participants were categorized into control (n = 3157) and hypoalbuminemia (n = 1168) groups. Serum albumin had a non-linear relationship with the risk of hypertension development. A genome-wide association study revealed 71 susceptibility loci associated with hypoalbuminemia. Among susceptibility loci, genetic variations at rs2894536 in LOC107986598 and rs10972486 in ATP8B5P were related to elevated blood pressure. Serum albumin (HR = 0.654, 95% CI 0.521–0.820) and polymorphisms of rs2894536 (HR = 1.176, 95% CI 1.015–1.361) and rs10972486 (HR = 1.152, 95% CI 1.009–1.316) were significant predictors of hypertension development. Increased albumin concentration instrumented by 2 hypoalbuminemia-associated SNPs (rs2894536 and rs10972486) was associated with decreased HRs for hypertension development (HR = 0.762, 95% CI 0.659–0.882 and HR = 0.759, 95% CI 0.656–0.878). Our study demonstrated that genetically determined hypoalbuminemia is a significant predictor of incipient hypertension.Jong Wook ChoiJoon-Sung ParkChang Hwa LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jong Wook Choi Joon-Sung Park Chang Hwa Lee Genetically determined hypoalbuminemia as a risk factor for hypertension: instrumental variable analysis
description	Abstract Hypoalbuminemia is associated with vascular endothelial dysfunction and the development of chronic cardiovascular diseases. However, the relationship between serum albumin concentration and blood pressure changes remains controversial. Community-based longitudinal cohort data collected from Korean Genome and Epidemiology Study were used in this study. Hypoalbuminemia was defined as a serum albumin concentration of ≤ 4.0 g/dL. A total of 4325 participants were categorized into control (n = 3157) and hypoalbuminemia (n = 1168) groups. Serum albumin had a non-linear relationship with the risk of hypertension development. A genome-wide association study revealed 71 susceptibility loci associated with hypoalbuminemia. Among susceptibility loci, genetic variations at rs2894536 in LOC107986598 and rs10972486 in ATP8B5P were related to elevated blood pressure. Serum albumin (HR = 0.654, 95% CI 0.521–0.820) and polymorphisms of rs2894536 (HR = 1.176, 95% CI 1.015–1.361) and rs10972486 (HR = 1.152, 95% CI 1.009–1.316) were significant predictors of hypertension development. Increased albumin concentration instrumented by 2 hypoalbuminemia-associated SNPs (rs2894536 and rs10972486) was associated with decreased HRs for hypertension development (HR = 0.762, 95% CI 0.659–0.882 and HR = 0.759, 95% CI 0.656–0.878). Our study demonstrated that genetically determined hypoalbuminemia is a significant predictor of incipient hypertension.
format	article
author	Jong Wook Choi Joon-Sung Park Chang Hwa Lee
author_facet	Jong Wook Choi Joon-Sung Park Chang Hwa Lee
author_sort	Jong Wook Choi
title	Genetically determined hypoalbuminemia as a risk factor for hypertension: instrumental variable analysis
title_short	Genetically determined hypoalbuminemia as a risk factor for hypertension: instrumental variable analysis
title_full	Genetically determined hypoalbuminemia as a risk factor for hypertension: instrumental variable analysis
title_fullStr	Genetically determined hypoalbuminemia as a risk factor for hypertension: instrumental variable analysis
title_full_unstemmed	Genetically determined hypoalbuminemia as a risk factor for hypertension: instrumental variable analysis
title_sort	genetically determined hypoalbuminemia as a risk factor for hypertension: instrumental variable analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e1cd63fe9f8242488f199fb3e4859f02
work_keys_str_mv	AT jongwookchoi geneticallydeterminedhypoalbuminemiaasariskfactorforhypertensioninstrumentalvariableanalysis AT joonsungpark geneticallydeterminedhypoalbuminemiaasariskfactorforhypertensioninstrumentalvariableanalysis AT changhwalee geneticallydeterminedhypoalbuminemiaasariskfactorforhypertensioninstrumentalvariableanalysis
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Genetically determined hypoalbuminemia as a risk factor for hypertension: instrumental variable analysis

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