Impact of image averaging on vessel detection using optical coherence tomography angiography in eyes with macular oedema and in healthy eyes.

<h4>Purpose</h4>To assess the repeatability of multiple automatic vessel density (VD) measurements and the effect of image averaging on vessel detection by optical coherence tomography angiography (OCTA).<h4>Methods</h4>An observational study was conducted in a series of heal...

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Autores principales:	Hugo Le Boité, Mardoche Chetrit, Ali Erginay, Sophie Bonnin, Carlo Lavia, Ramin Tadayoni, Aude Couturier
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e1ce3e586fcd44c08193d66f151dbd58
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spelling	oai:doaj.org-article:e1ce3e586fcd44c08193d66f151dbd582021-12-02T20:16:37ZImpact of image averaging on vessel detection using optical coherence tomography angiography in eyes with macular oedema and in healthy eyes.1932-620310.1371/journal.pone.0257859https://doaj.org/article/e1ce3e586fcd44c08193d66f151dbd582021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257859https://doaj.org/toc/1932-6203<h4>Purpose</h4>To assess the repeatability of multiple automatic vessel density (VD) measurements and the effect of image averaging on vessel detection by optical coherence tomography angiography (OCTA).<h4>Methods</h4>An observational study was conducted in a series of healthy volunteers and patients with macular oedema. Five sequential OCTA images were acquired for each eye using the OptoVue HD device. The effect of the averaging of the 5 acquisitions on vessel detection was analysed quantitatively using a pixel-by-pixel automated analysis. In addition, two independent retina experts qualitatively assessed the change in vessel detection in averaged images segmented in 9 boxes and compared to the first non-averaged image.<h4>Results</h4>The automatic VD measurement in OCTA images showed a good repeatability with an overall mean intra-class correlation coefficient (ICC) of 0.924. The mean ICC was higher in healthy eyes compared to eyes with macular oedema (0.877 versus 0.960; p < 0.001) and in the superficial vascular plexus versus the deep vascular complex (0.967 versus 0.888; p = 0.001). The quantitative analysis of the effect of the averaging showed that averaged images had a mean gain of 790.4 pixels/box, located around or completing interruptions in the vessel walls, and a mean loss of 727.2 pixels/box. The qualitative analysis of the averaged images showed that 99.6% of boxes in the averaged images had a gain in vessel detection (i.e., vessels detected in the averaged image but not in the non-averaged image). The loss of pixels was due to a reduction in background noise and motion artifacts in all cases and no case of loss of vessel detection was observed.<h4>Conclusion</h4>The automatic VD measurement using the OptoVue HD device showed a good repeatability in 5 acquisitions in a row setting. Averaging images increased vessel detection, and in about a third of boxes, decreased the background noise, both in healthy eyes and, in a greater proportion, in eyes with macular oedema.Hugo Le BoitéMardoche ChetritAli ErginaySophie BonninCarlo LaviaRamin TadayoniAude CouturierPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0257859 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hugo Le Boité Mardoche Chetrit Ali Erginay Sophie Bonnin Carlo Lavia Ramin Tadayoni Aude Couturier Impact of image averaging on vessel detection using optical coherence tomography angiography in eyes with macular oedema and in healthy eyes.
description	<h4>Purpose</h4>To assess the repeatability of multiple automatic vessel density (VD) measurements and the effect of image averaging on vessel detection by optical coherence tomography angiography (OCTA).<h4>Methods</h4>An observational study was conducted in a series of healthy volunteers and patients with macular oedema. Five sequential OCTA images were acquired for each eye using the OptoVue HD device. The effect of the averaging of the 5 acquisitions on vessel detection was analysed quantitatively using a pixel-by-pixel automated analysis. In addition, two independent retina experts qualitatively assessed the change in vessel detection in averaged images segmented in 9 boxes and compared to the first non-averaged image.<h4>Results</h4>The automatic VD measurement in OCTA images showed a good repeatability with an overall mean intra-class correlation coefficient (ICC) of 0.924. The mean ICC was higher in healthy eyes compared to eyes with macular oedema (0.877 versus 0.960; p < 0.001) and in the superficial vascular plexus versus the deep vascular complex (0.967 versus 0.888; p = 0.001). The quantitative analysis of the effect of the averaging showed that averaged images had a mean gain of 790.4 pixels/box, located around or completing interruptions in the vessel walls, and a mean loss of 727.2 pixels/box. The qualitative analysis of the averaged images showed that 99.6% of boxes in the averaged images had a gain in vessel detection (i.e., vessels detected in the averaged image but not in the non-averaged image). The loss of pixels was due to a reduction in background noise and motion artifacts in all cases and no case of loss of vessel detection was observed.<h4>Conclusion</h4>The automatic VD measurement using the OptoVue HD device showed a good repeatability in 5 acquisitions in a row setting. Averaging images increased vessel detection, and in about a third of boxes, decreased the background noise, both in healthy eyes and, in a greater proportion, in eyes with macular oedema.
format	article
author	Hugo Le Boité Mardoche Chetrit Ali Erginay Sophie Bonnin Carlo Lavia Ramin Tadayoni Aude Couturier
author_facet	Hugo Le Boité Mardoche Chetrit Ali Erginay Sophie Bonnin Carlo Lavia Ramin Tadayoni Aude Couturier
author_sort	Hugo Le Boité
title	Impact of image averaging on vessel detection using optical coherence tomography angiography in eyes with macular oedema and in healthy eyes.
title_short	Impact of image averaging on vessel detection using optical coherence tomography angiography in eyes with macular oedema and in healthy eyes.
title_full	Impact of image averaging on vessel detection using optical coherence tomography angiography in eyes with macular oedema and in healthy eyes.
title_fullStr	Impact of image averaging on vessel detection using optical coherence tomography angiography in eyes with macular oedema and in healthy eyes.
title_full_unstemmed	Impact of image averaging on vessel detection using optical coherence tomography angiography in eyes with macular oedema and in healthy eyes.
title_sort	impact of image averaging on vessel detection using optical coherence tomography angiography in eyes with macular oedema and in healthy eyes.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e1ce3e586fcd44c08193d66f151dbd58
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Impact of image averaging on vessel detection using optical coherence tomography angiography in eyes with macular oedema and in healthy eyes.

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