Pan-cancer deconvolution of tumour composition using DNA methylation

Determining the extent of immune cell infiltration into solid tumours is essential for adequate therapeutic response. Here the authors develop a DNA methylation-based approach for tumour cell fraction deconvolution and analyse tumour composition and genomics across a wide spectrum of solid cancers.

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Autores principales:	Ankur Chakravarthy, Andrew Furness, Kroopa Joshi, Ehsan Ghorani, Kirsty Ford, Matthew J. Ward, Emma V. King, Matt Lechner, Teresa Marafioti, Sergio A. Quezada, Gareth J. Thomas, Andrew Feber, Tim R. Fenton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e1cf9d7772ff44b4a8372f27b4755fbd
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spelling	oai:doaj.org-article:e1cf9d7772ff44b4a8372f27b4755fbd2021-12-02T17:32:03ZPan-cancer deconvolution of tumour composition using DNA methylation10.1038/s41467-018-05570-12041-1723https://doaj.org/article/e1cf9d7772ff44b4a8372f27b4755fbd2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05570-1https://doaj.org/toc/2041-1723Determining the extent of immune cell infiltration into solid tumours is essential for adequate therapeutic response. Here the authors develop a DNA methylation-based approach for tumour cell fraction deconvolution and analyse tumour composition and genomics across a wide spectrum of solid cancers.Ankur ChakravarthyAndrew FurnessKroopa JoshiEhsan GhoraniKirsty FordMatthew J. WardEmma V. KingMatt LechnerTeresa MarafiotiSergio A. QuezadaGareth J. ThomasAndrew FeberTim R. FentonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ankur Chakravarthy Andrew Furness Kroopa Joshi Ehsan Ghorani Kirsty Ford Matthew J. Ward Emma V. King Matt Lechner Teresa Marafioti Sergio A. Quezada Gareth J. Thomas Andrew Feber Tim R. Fenton Pan-cancer deconvolution of tumour composition using DNA methylation
description	Determining the extent of immune cell infiltration into solid tumours is essential for adequate therapeutic response. Here the authors develop a DNA methylation-based approach for tumour cell fraction deconvolution and analyse tumour composition and genomics across a wide spectrum of solid cancers.
format	article
author	Ankur Chakravarthy Andrew Furness Kroopa Joshi Ehsan Ghorani Kirsty Ford Matthew J. Ward Emma V. King Matt Lechner Teresa Marafioti Sergio A. Quezada Gareth J. Thomas Andrew Feber Tim R. Fenton
author_facet	Ankur Chakravarthy Andrew Furness Kroopa Joshi Ehsan Ghorani Kirsty Ford Matthew J. Ward Emma V. King Matt Lechner Teresa Marafioti Sergio A. Quezada Gareth J. Thomas Andrew Feber Tim R. Fenton
author_sort	Ankur Chakravarthy
title	Pan-cancer deconvolution of tumour composition using DNA methylation
title_short	Pan-cancer deconvolution of tumour composition using DNA methylation
title_full	Pan-cancer deconvolution of tumour composition using DNA methylation
title_fullStr	Pan-cancer deconvolution of tumour composition using DNA methylation
title_full_unstemmed	Pan-cancer deconvolution of tumour composition using DNA methylation
title_sort	pan-cancer deconvolution of tumour composition using dna methylation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e1cf9d7772ff44b4a8372f27b4755fbd
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Pan-cancer deconvolution of tumour composition using DNA methylation

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