Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis

Abstract Background Extracellular vesicles (EVs) are recognized as novel cell-free therapeutics. Non-alcoholic steatohepatitis (NASH) remains a critical health problem. Herein, we show that EVs from pan peroxisome proliferator-activated receptor agonist-primed induced mesenchymal stem cell (pan PPAR...

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Autores principales:	Jimin Kim, Seul Ki Lee, Seon-Yeong Jeong, Hye Jin Cho, Joonghoon Park, Tae Min Kim, Soo Kim
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Non-alcoholic steatohepatitis Induced mesenchymal stem cells Extracellular vesicles Steatosis Inflammation Regeneration Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/e1d98e698c944ceca10abcb6d3e7f25c
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spelling	oai:doaj.org-article:e1d98e698c944ceca10abcb6d3e7f25c2021-11-21T12:29:25ZCargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis10.1186/s12951-021-01120-y1477-3155https://doaj.org/article/e1d98e698c944ceca10abcb6d3e7f25c2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01120-yhttps://doaj.org/toc/1477-3155Abstract Background Extracellular vesicles (EVs) are recognized as novel cell-free therapeutics. Non-alcoholic steatohepatitis (NASH) remains a critical health problem. Herein, we show that EVs from pan peroxisome proliferator-activated receptor agonist-primed induced mesenchymal stem cell (pan PPAR-iMSC-EVs) has unique cargo protein signatures, and demonstrate its therapeutic function in NASH. Results A unique protein signatures were identified in pan PPAR-iMSC-EVs against those from non-stimulated iMSC-EVs. NASH mice receiving pan PPAR-iMSC-EVs showed reduced steatotic changes and ameliorated ER stress and mitochondiral oxidative stress induced by inflammation. Moreover, pan PPAR-iMSC-EVs promoted liver regeneration via inhibiting apoptosis and enhancing proliferation. Conclusions We conclude that our strategy for enriching unique cargo proteins in EVs may facilitate the development of novel therapeutic option for NASH. Graphical AbstractJimin KimSeul Ki LeeSeon-Yeong JeongHye Jin ChoJoonghoon ParkTae Min KimSoo KimBMCarticleNon-alcoholic steatohepatitisInduced mesenchymal stem cellsExtracellular vesiclesSteatosisInflammationRegenerationBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Non-alcoholic steatohepatitis Induced mesenchymal stem cells Extracellular vesicles Steatosis Inflammation Regeneration Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Non-alcoholic steatohepatitis Induced mesenchymal stem cells Extracellular vesicles Steatosis Inflammation Regeneration Biotechnology TP248.13-248.65 Medical technology R855-855.5 Jimin Kim Seul Ki Lee Seon-Yeong Jeong Hye Jin Cho Joonghoon Park Tae Min Kim Soo Kim Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis
description	Abstract Background Extracellular vesicles (EVs) are recognized as novel cell-free therapeutics. Non-alcoholic steatohepatitis (NASH) remains a critical health problem. Herein, we show that EVs from pan peroxisome proliferator-activated receptor agonist-primed induced mesenchymal stem cell (pan PPAR-iMSC-EVs) has unique cargo protein signatures, and demonstrate its therapeutic function in NASH. Results A unique protein signatures were identified in pan PPAR-iMSC-EVs against those from non-stimulated iMSC-EVs. NASH mice receiving pan PPAR-iMSC-EVs showed reduced steatotic changes and ameliorated ER stress and mitochondiral oxidative stress induced by inflammation. Moreover, pan PPAR-iMSC-EVs promoted liver regeneration via inhibiting apoptosis and enhancing proliferation. Conclusions We conclude that our strategy for enriching unique cargo proteins in EVs may facilitate the development of novel therapeutic option for NASH. Graphical Abstract
format	article
author	Jimin Kim Seul Ki Lee Seon-Yeong Jeong Hye Jin Cho Joonghoon Park Tae Min Kim Soo Kim
author_facet	Jimin Kim Seul Ki Lee Seon-Yeong Jeong Hye Jin Cho Joonghoon Park Tae Min Kim Soo Kim
author_sort	Jimin Kim
title	Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis
title_short	Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis
title_full	Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis
title_fullStr	Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis
title_full_unstemmed	Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis
title_sort	cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e1d98e698c944ceca10abcb6d3e7f25c
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Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis

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