Replication vesicles are load- and choke-points in the hepatitis C virus lifecycle.
Hepatitis C virus (HCV) infection develops into chronicity in 80% of all patients, characterized by persistent low-level replication. To understand how the virus establishes its tightly controlled intracellular RNA replication cycle, we developed the first detailed mathematical model of the initial...
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Main Authors: | Marco Binder, Nurgazy Sulaimanov, Diana Clausznitzer, Manuel Schulze, Christian M Hüber, Simon M Lenz, Johannes P Schlöder, Martin Trippler, Ralf Bartenschlager, Volker Lohmann, Lars Kaderali |
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Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2013
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Online Access: | https://doaj.org/article/e1dc895e827a4dd7b115633d1eeb9a6a |
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