Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function

Beyond its role on the conversion of nutrients into energy and biomass, cellular metabolism is actively involved in the control of many physiological processes. Among these, it is becoming increasingly evident that specific metabolic pathways are associated with the phenotype of several immune cell...

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Autores principales:	Lídia Fortuny, Carlos Sebastián
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sirtuins metabolism immune cells immune-related diseases Genetics QH426-470
Acceso en línea:	https://doaj.org/article/e1de2d55d98b45728b08fb6272c1f5b6
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spelling	oai:doaj.org-article:e1de2d55d98b45728b08fb6272c1f5b62021-11-25T17:40:57ZSirtuins as Metabolic Regulators of Immune Cells Phenotype and Function10.3390/genes121116982073-4425https://doaj.org/article/e1de2d55d98b45728b08fb6272c1f5b62021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1698https://doaj.org/toc/2073-4425Beyond its role on the conversion of nutrients into energy and biomass, cellular metabolism is actively involved in the control of many physiological processes. Among these, it is becoming increasingly evident that specific metabolic pathways are associated with the phenotype of several immune cell types and, importantly, are crucial in controlling their differentiation, proliferation, and effector functions, thus shaping the immune response against pathogens and tumors. In this context, data generated over the last decade have uncovered mammalian sirtuins as important regulators of cellular metabolism, immune cell function, and cancer. Here, we summarize our current knowledge on the roles of this family of protein deacylases on the metabolic control of immune cells and their implications on immune-related diseases and cancer.Lídia FortunyCarlos SebastiánMDPI AGarticlesirtuinsmetabolismimmune cellsimmune-related diseasesGeneticsQH426-470ENGenes, Vol 12, Iss 1698, p 1698 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sirtuins metabolism immune cells immune-related diseases Genetics QH426-470
spellingShingle	sirtuins metabolism immune cells immune-related diseases Genetics QH426-470 Lídia Fortuny Carlos Sebastián Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function
description	Beyond its role on the conversion of nutrients into energy and biomass, cellular metabolism is actively involved in the control of many physiological processes. Among these, it is becoming increasingly evident that specific metabolic pathways are associated with the phenotype of several immune cell types and, importantly, are crucial in controlling their differentiation, proliferation, and effector functions, thus shaping the immune response against pathogens and tumors. In this context, data generated over the last decade have uncovered mammalian sirtuins as important regulators of cellular metabolism, immune cell function, and cancer. Here, we summarize our current knowledge on the roles of this family of protein deacylases on the metabolic control of immune cells and their implications on immune-related diseases and cancer.
format	article
author	Lídia Fortuny Carlos Sebastián
author_facet	Lídia Fortuny Carlos Sebastián
author_sort	Lídia Fortuny
title	Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function
title_short	Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function
title_full	Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function
title_fullStr	Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function
title_full_unstemmed	Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function
title_sort	sirtuins as metabolic regulators of immune cells phenotype and function
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e1de2d55d98b45728b08fb6272c1f5b6
work_keys_str_mv	AT lidiafortuny sirtuinsasmetabolicregulatorsofimmunecellsphenotypeandfunction AT carlossebastian sirtuinsasmetabolicregulatorsofimmunecellsphenotypeandfunction
_version_	1718412135950712832

Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function

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