Repression of GSK3 restores NK cell cytotoxicity in AML patients

Natural killer cells of acute myeloid leukaemia patients lack cytotoxic activity. Here the authors show that these cells have elevated GSK3β, and that its inhibition prolongs survival of mice transplanted with human AML and stimulates NK cytotoxicity via increased adhesion of NK cells to their targe...

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Autores principales:	Reshmi Parameswaran, Parameswaran Ramakrishnan, Stephen A. Moreton, Zhiqiang Xia, Yongchun Hou, Dean A. Lee, Kalpana Gupta, Marcos deLima, Rose C. Beck, David N. Wald
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e1e049514d104978859f1c4b3b7f9b43
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spelling	oai:doaj.org-article:e1e049514d104978859f1c4b3b7f9b432021-12-02T14:40:15ZRepression of GSK3 restores NK cell cytotoxicity in AML patients10.1038/ncomms111542041-1723https://doaj.org/article/e1e049514d104978859f1c4b3b7f9b432016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11154https://doaj.org/toc/2041-1723Natural killer cells of acute myeloid leukaemia patients lack cytotoxic activity. Here the authors show that these cells have elevated GSK3β, and that its inhibition prolongs survival of mice transplanted with human AML and stimulates NK cytotoxicity via increased adhesion of NK cells to their targets.Reshmi ParameswaranParameswaran RamakrishnanStephen A. MoretonZhiqiang XiaYongchun HouDean A. LeeKalpana GuptaMarcos deLimaRose C. BeckDavid N. WaldNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Reshmi Parameswaran Parameswaran Ramakrishnan Stephen A. Moreton Zhiqiang Xia Yongchun Hou Dean A. Lee Kalpana Gupta Marcos deLima Rose C. Beck David N. Wald Repression of GSK3 restores NK cell cytotoxicity in AML patients
description	Natural killer cells of acute myeloid leukaemia patients lack cytotoxic activity. Here the authors show that these cells have elevated GSK3β, and that its inhibition prolongs survival of mice transplanted with human AML and stimulates NK cytotoxicity via increased adhesion of NK cells to their targets.
format	article
author	Reshmi Parameswaran Parameswaran Ramakrishnan Stephen A. Moreton Zhiqiang Xia Yongchun Hou Dean A. Lee Kalpana Gupta Marcos deLima Rose C. Beck David N. Wald
author_facet	Reshmi Parameswaran Parameswaran Ramakrishnan Stephen A. Moreton Zhiqiang Xia Yongchun Hou Dean A. Lee Kalpana Gupta Marcos deLima Rose C. Beck David N. Wald
author_sort	Reshmi Parameswaran
title	Repression of GSK3 restores NK cell cytotoxicity in AML patients
title_short	Repression of GSK3 restores NK cell cytotoxicity in AML patients
title_full	Repression of GSK3 restores NK cell cytotoxicity in AML patients
title_fullStr	Repression of GSK3 restores NK cell cytotoxicity in AML patients
title_full_unstemmed	Repression of GSK3 restores NK cell cytotoxicity in AML patients
title_sort	repression of gsk3 restores nk cell cytotoxicity in aml patients
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e1e049514d104978859f1c4b3b7f9b43
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Repression of GSK3 restores NK cell cytotoxicity in AML patients

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