Comparison of Individual Retinal Layer Thicknesses between Highly Myopic Eyes and Normal Control Eyes Using Retinal Layer Segmentation Analysis

Abstract The incidence of myopia is increasing worldwide, and the investigation on pathophysiology of myopia is becoming more important. This retrospective study aimed to compare the thicknesses of individual retinal layers between high-myopic and control eyes, and to evaluate the effects of age and...

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Autores principales:	Jin Hyung Kim, Sung Hoon Lee, Jae Yong Han, Hyun Goo Kang, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Min Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e1e0aa6c73c044199f97cf4827b26fbc
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spelling	oai:doaj.org-article:e1e0aa6c73c044199f97cf4827b26fbc2021-12-02T15:09:38ZComparison of Individual Retinal Layer Thicknesses between Highly Myopic Eyes and Normal Control Eyes Using Retinal Layer Segmentation Analysis10.1038/s41598-019-50306-w2045-2322https://doaj.org/article/e1e0aa6c73c044199f97cf4827b26fbc2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-50306-whttps://doaj.org/toc/2045-2322Abstract The incidence of myopia is increasing worldwide, and the investigation on pathophysiology of myopia is becoming more important. This retrospective study aimed to compare the thicknesses of individual retinal layers between high-myopic and control eyes, and to evaluate the effects of age and sex on each retinal layer thickness. We assessed 164 subjects and divided them into two groups based on axial length (AL) (i.e., high-myopic group (AL ≥ 26 mm) and control group (AL < 26 mm)). Individual retinal layer thicknesses of five subfields in the macula were measured using automated retinal segmentation software packaged with the spectral-domain optical coherence tomography and were compared. In high-myopia group, the thicknesses of total retina and all individual retinal layers in central and entire perifoveal subfields were significantly thicker than the corresponding layers in control group after adjustment for ocular magnification (all P < 0.05). There were no significant effects of sex on individual retinal thicknesses, and age had less negative effects on the thicknesses of retina layers in high-myopic eyes than normal eyes. Axially elongated, non-pathologic highly myopic eyes had different structural features than control eyes, with significantly greater individual macular layer thicknesses independent of sex or age.Jin Hyung KimSung Hoon LeeJae Yong HanHyun Goo KangSuk Ho ByeonSung Soo KimHyoung Jun KohSung Chul LeeMin KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jin Hyung Kim Sung Hoon Lee Jae Yong Han Hyun Goo Kang Suk Ho Byeon Sung Soo Kim Hyoung Jun Koh Sung Chul Lee Min Kim Comparison of Individual Retinal Layer Thicknesses between Highly Myopic Eyes and Normal Control Eyes Using Retinal Layer Segmentation Analysis
description	Abstract The incidence of myopia is increasing worldwide, and the investigation on pathophysiology of myopia is becoming more important. This retrospective study aimed to compare the thicknesses of individual retinal layers between high-myopic and control eyes, and to evaluate the effects of age and sex on each retinal layer thickness. We assessed 164 subjects and divided them into two groups based on axial length (AL) (i.e., high-myopic group (AL ≥ 26 mm) and control group (AL < 26 mm)). Individual retinal layer thicknesses of five subfields in the macula were measured using automated retinal segmentation software packaged with the spectral-domain optical coherence tomography and were compared. In high-myopia group, the thicknesses of total retina and all individual retinal layers in central and entire perifoveal subfields were significantly thicker than the corresponding layers in control group after adjustment for ocular magnification (all P < 0.05). There were no significant effects of sex on individual retinal thicknesses, and age had less negative effects on the thicknesses of retina layers in high-myopic eyes than normal eyes. Axially elongated, non-pathologic highly myopic eyes had different structural features than control eyes, with significantly greater individual macular layer thicknesses independent of sex or age.
format	article
author	Jin Hyung Kim Sung Hoon Lee Jae Yong Han Hyun Goo Kang Suk Ho Byeon Sung Soo Kim Hyoung Jun Koh Sung Chul Lee Min Kim
author_facet	Jin Hyung Kim Sung Hoon Lee Jae Yong Han Hyun Goo Kang Suk Ho Byeon Sung Soo Kim Hyoung Jun Koh Sung Chul Lee Min Kim
author_sort	Jin Hyung Kim
title	Comparison of Individual Retinal Layer Thicknesses between Highly Myopic Eyes and Normal Control Eyes Using Retinal Layer Segmentation Analysis
title_short	Comparison of Individual Retinal Layer Thicknesses between Highly Myopic Eyes and Normal Control Eyes Using Retinal Layer Segmentation Analysis
title_full	Comparison of Individual Retinal Layer Thicknesses between Highly Myopic Eyes and Normal Control Eyes Using Retinal Layer Segmentation Analysis
title_fullStr	Comparison of Individual Retinal Layer Thicknesses between Highly Myopic Eyes and Normal Control Eyes Using Retinal Layer Segmentation Analysis
title_full_unstemmed	Comparison of Individual Retinal Layer Thicknesses between Highly Myopic Eyes and Normal Control Eyes Using Retinal Layer Segmentation Analysis
title_sort	comparison of individual retinal layer thicknesses between highly myopic eyes and normal control eyes using retinal layer segmentation analysis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e1e0aa6c73c044199f97cf4827b26fbc
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Comparison of Individual Retinal Layer Thicknesses between Highly Myopic Eyes and Normal Control Eyes Using Retinal Layer Segmentation Analysis

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