Constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy

Abstract Stem cell therapy is widely recognized as a promising strategy for exerting therapeutic effects after injury in degenerative diseases. However, limitations such as low cell retention and survival rates after transplantation exist in clinical applications. In recent years, emerging biomateri...

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Autores principales:	Xiaotong Zhao, Qiong Li, Zhikun Guo, Zongjin Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Engineered microenvironment Biomaterials Scaffold Stem cells Cellular therapy Tissue regeneration Medicine (General) R5-920 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/e1e1594ff95b49ac9d7204c15138d8b8
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id	oai:doaj.org-article:e1e1594ff95b49ac9d7204c15138d8b8
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spelling	oai:doaj.org-article:e1e1594ff95b49ac9d7204c15138d8b82021-11-28T12:06:21ZConstructing a cell microenvironment with biomaterial scaffolds for stem cell therapy10.1186/s13287-021-02650-w1757-6512https://doaj.org/article/e1e1594ff95b49ac9d7204c15138d8b82021-11-01T00:00:00Zhttps://doi.org/10.1186/s13287-021-02650-whttps://doaj.org/toc/1757-6512Abstract Stem cell therapy is widely recognized as a promising strategy for exerting therapeutic effects after injury in degenerative diseases. However, limitations such as low cell retention and survival rates after transplantation exist in clinical applications. In recent years, emerging biomaterials that provide a supportable cellular microenvironment for transplanted cells have optimized the therapeutic efficacy of stem cells in injured tissues or organs. Advances in the engineered microenvironment are revolutionizing our understanding of stem cell-based therapies by co-transplanting with synthetic and tissue-derived biomaterials, which offer a scaffold for stem cells and propose an unprecedented opportunity to further employ significant influences in tissue repair and regeneration.Xiaotong ZhaoQiong LiZhikun GuoZongjin LiBMCarticleEngineered microenvironmentBiomaterialsScaffoldStem cellsCellular therapyTissue regenerationMedicine (General)R5-920BiochemistryQD415-436ENStem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Engineered microenvironment Biomaterials Scaffold Stem cells Cellular therapy Tissue regeneration Medicine (General) R5-920 Biochemistry QD415-436
spellingShingle	Engineered microenvironment Biomaterials Scaffold Stem cells Cellular therapy Tissue regeneration Medicine (General) R5-920 Biochemistry QD415-436 Xiaotong Zhao Qiong Li Zhikun Guo Zongjin Li Constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy
description	Abstract Stem cell therapy is widely recognized as a promising strategy for exerting therapeutic effects after injury in degenerative diseases. However, limitations such as low cell retention and survival rates after transplantation exist in clinical applications. In recent years, emerging biomaterials that provide a supportable cellular microenvironment for transplanted cells have optimized the therapeutic efficacy of stem cells in injured tissues or organs. Advances in the engineered microenvironment are revolutionizing our understanding of stem cell-based therapies by co-transplanting with synthetic and tissue-derived biomaterials, which offer a scaffold for stem cells and propose an unprecedented opportunity to further employ significant influences in tissue repair and regeneration.
format	article
author	Xiaotong Zhao Qiong Li Zhikun Guo Zongjin Li
author_facet	Xiaotong Zhao Qiong Li Zhikun Guo Zongjin Li
author_sort	Xiaotong Zhao
title	Constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy
title_short	Constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy
title_full	Constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy
title_fullStr	Constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy
title_full_unstemmed	Constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy
title_sort	constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e1e1594ff95b49ac9d7204c15138d8b8
work_keys_str_mv	AT xiaotongzhao constructingacellmicroenvironmentwithbiomaterialscaffoldsforstemcelltherapy AT qiongli constructingacellmicroenvironmentwithbiomaterialscaffoldsforstemcelltherapy AT zhikunguo constructingacellmicroenvironmentwithbiomaterialscaffoldsforstemcelltherapy AT zongjinli constructingacellmicroenvironmentwithbiomaterialscaffoldsforstemcelltherapy
_version_	1718408230333317120

Constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy

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