Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes

Abstract The role of androgens in metabolism with respect to sex-specific disease associations is poorly understood. Therefore, we aimed to provide molecular signatures in plasma and urine of androgen action in a sex-specific manner using state-of-the-art metabolomics techniques. Our study populatio...

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Autores principales:	Uwe Piontek, Henri Wallaschofski, Gabi Kastenmüller, Karsten Suhre, Henry Völzke, Kieu Trinh Do, Anna Artati, Matthias Nauck, Jerzy Adamski, Nele Friedrich, Maik Pietzner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e1e50af573bf4acd84e0bfe53cf0796c
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spelling	oai:doaj.org-article:e1e50af573bf4acd84e0bfe53cf0796c2021-12-02T16:06:42ZSex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes10.1038/s41598-017-02367-y2045-2322https://doaj.org/article/e1e50af573bf4acd84e0bfe53cf0796c2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02367-yhttps://doaj.org/toc/2045-2322Abstract The role of androgens in metabolism with respect to sex-specific disease associations is poorly understood. Therefore, we aimed to provide molecular signatures in plasma and urine of androgen action in a sex-specific manner using state-of-the-art metabolomics techniques. Our study population consisted of 430 men and 343 women, aged 20–80 years, who were recruited for the cross-sectional population-based Study of Health in Pomerania (SHIP-TREND), Germany. We used linear regression models to identify associations between testosterone, androstenedione and dehydroepiandrosterone-sulfate (DHEAS) as well as sex hormone-binding globulin and plasma or urine metabolites measured by mass spectrometry. The analyses revealed major sex-specific differences in androgen-associated metabolites, particularly for levels of urate, lipids and metabolic surrogates of lifestyle factors, like cotinine or piperine. In women, in particular in the postmenopausal state, androgens showed a greater impact on the metabolome than in men (especially DHEAS and lipids were highly related in women). We observed a novel association of androstenedione on the metabolism of biogenic amines and only a small sex-overlap of associations within steroid metabolism. The present study yields new insights in the interaction between androgens and metabolism, especially about their implication in female metabolism.Uwe PiontekHenri WallaschofskiGabi KastenmüllerKarsten SuhreHenry VölzkeKieu Trinh DoAnna ArtatiMatthias NauckJerzy AdamskiNele FriedrichMaik PietznerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Uwe Piontek Henri Wallaschofski Gabi Kastenmüller Karsten Suhre Henry Völzke Kieu Trinh Do Anna Artati Matthias Nauck Jerzy Adamski Nele Friedrich Maik Pietzner Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes
description	Abstract The role of androgens in metabolism with respect to sex-specific disease associations is poorly understood. Therefore, we aimed to provide molecular signatures in plasma and urine of androgen action in a sex-specific manner using state-of-the-art metabolomics techniques. Our study population consisted of 430 men and 343 women, aged 20–80 years, who were recruited for the cross-sectional population-based Study of Health in Pomerania (SHIP-TREND), Germany. We used linear regression models to identify associations between testosterone, androstenedione and dehydroepiandrosterone-sulfate (DHEAS) as well as sex hormone-binding globulin and plasma or urine metabolites measured by mass spectrometry. The analyses revealed major sex-specific differences in androgen-associated metabolites, particularly for levels of urate, lipids and metabolic surrogates of lifestyle factors, like cotinine or piperine. In women, in particular in the postmenopausal state, androgens showed a greater impact on the metabolome than in men (especially DHEAS and lipids were highly related in women). We observed a novel association of androstenedione on the metabolism of biogenic amines and only a small sex-overlap of associations within steroid metabolism. The present study yields new insights in the interaction between androgens and metabolism, especially about their implication in female metabolism.
format	article
author	Uwe Piontek Henri Wallaschofski Gabi Kastenmüller Karsten Suhre Henry Völzke Kieu Trinh Do Anna Artati Matthias Nauck Jerzy Adamski Nele Friedrich Maik Pietzner
author_facet	Uwe Piontek Henri Wallaschofski Gabi Kastenmüller Karsten Suhre Henry Völzke Kieu Trinh Do Anna Artati Matthias Nauck Jerzy Adamski Nele Friedrich Maik Pietzner
author_sort	Uwe Piontek
title	Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes
title_short	Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes
title_full	Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes
title_fullStr	Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes
title_full_unstemmed	Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes
title_sort	sex-specific metabolic profiles of androgens and its main binding protein shbg in a middle aged population without diabetes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e1e50af573bf4acd84e0bfe53cf0796c
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Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes

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