Acute Ischemic Stroke With Mild Symptoms–To Thrombolyse or Not to Thrombolyse?

Management of stroke with minor symptoms may represent a therapeutical dilemma as the hemorrhage risk of acute thrombolytic therapy may eventually outweigh the stroke severity. However, around 30% of patients presenting with minor stroke symptoms are ultimately left with disability. The objective of...

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Autores principales:	Julia Ferrari, Audrey Reynolds, Michael Knoflach, Marek Sykora
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	minor stroke thrombolysis/thrombolytic agents DAPT (dual antiplatelet therapy) very mild severity rapidly improving stroke symptoms Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e1e54074ef1b447cbf4b0dd30c1859a0
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spelling	oai:doaj.org-article:e1e54074ef1b447cbf4b0dd30c1859a02021-11-18T08:57:13ZAcute Ischemic Stroke With Mild Symptoms–To Thrombolyse or Not to Thrombolyse?1664-229510.3389/fneur.2021.760813https://doaj.org/article/e1e54074ef1b447cbf4b0dd30c1859a02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.760813/fullhttps://doaj.org/toc/1664-2295Management of stroke with minor symptoms may represent a therapeutical dilemma as the hemorrhage risk of acute thrombolytic therapy may eventually outweigh the stroke severity. However, around 30% of patients presenting with minor stroke symptoms are ultimately left with disability. The objective of this review is to evaluate the current literature and evidence regarding the management of minor stroke, with a particular emphasis on the role of IV thrombolysis. Definition of minor stroke, pre-hospital recognition of minor stroke and stroke of unknown onset are discussed together with neuroimaging aspects and existing evidence for IV thrombolysis in minor strokes. Though current guidelines advise against the use of thrombolysis in those without clearly disabling symptoms due to a paucity of evidence, advanced imaging techniques may be able to identify those likely to benefit. Further research on this topic is ongoing.Julia FerrariAudrey ReynoldsMichael KnoflachMarek SykoraMarek SykoraFrontiers Media S.A.articleminor strokethrombolysis/thrombolytic agentsDAPT (dual antiplatelet therapy)very mild severityrapidly improving stroke symptomsNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	minor stroke thrombolysis/thrombolytic agents DAPT (dual antiplatelet therapy) very mild severity rapidly improving stroke symptoms Neurology. Diseases of the nervous system RC346-429
spellingShingle	minor stroke thrombolysis/thrombolytic agents DAPT (dual antiplatelet therapy) very mild severity rapidly improving stroke symptoms Neurology. Diseases of the nervous system RC346-429 Julia Ferrari Audrey Reynolds Michael Knoflach Marek Sykora Marek Sykora Acute Ischemic Stroke With Mild Symptoms–To Thrombolyse or Not to Thrombolyse?
description	Management of stroke with minor symptoms may represent a therapeutical dilemma as the hemorrhage risk of acute thrombolytic therapy may eventually outweigh the stroke severity. However, around 30% of patients presenting with minor stroke symptoms are ultimately left with disability. The objective of this review is to evaluate the current literature and evidence regarding the management of minor stroke, with a particular emphasis on the role of IV thrombolysis. Definition of minor stroke, pre-hospital recognition of minor stroke and stroke of unknown onset are discussed together with neuroimaging aspects and existing evidence for IV thrombolysis in minor strokes. Though current guidelines advise against the use of thrombolysis in those without clearly disabling symptoms due to a paucity of evidence, advanced imaging techniques may be able to identify those likely to benefit. Further research on this topic is ongoing.
format	article
author	Julia Ferrari Audrey Reynolds Michael Knoflach Marek Sykora Marek Sykora
author_facet	Julia Ferrari Audrey Reynolds Michael Knoflach Marek Sykora Marek Sykora
author_sort	Julia Ferrari
title	Acute Ischemic Stroke With Mild Symptoms–To Thrombolyse or Not to Thrombolyse?
title_short	Acute Ischemic Stroke With Mild Symptoms–To Thrombolyse or Not to Thrombolyse?
title_full	Acute Ischemic Stroke With Mild Symptoms–To Thrombolyse or Not to Thrombolyse?
title_fullStr	Acute Ischemic Stroke With Mild Symptoms–To Thrombolyse or Not to Thrombolyse?
title_full_unstemmed	Acute Ischemic Stroke With Mild Symptoms–To Thrombolyse or Not to Thrombolyse?
title_sort	acute ischemic stroke with mild symptoms–to thrombolyse or not to thrombolyse?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e1e54074ef1b447cbf4b0dd30c1859a0
work_keys_str_mv	AT juliaferrari acuteischemicstrokewithmildsymptomstothrombolyseornottothrombolyse AT audreyreynolds acuteischemicstrokewithmildsymptomstothrombolyseornottothrombolyse AT michaelknoflach acuteischemicstrokewithmildsymptomstothrombolyseornottothrombolyse AT mareksykora acuteischemicstrokewithmildsymptomstothrombolyseornottothrombolyse AT mareksykora acuteischemicstrokewithmildsymptomstothrombolyseornottothrombolyse
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Acute Ischemic Stroke With Mild Symptoms–To Thrombolyse or Not to Thrombolyse?

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