Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis

Hasan Ulusoy,1 Gurkan Akgol,2 Arif Gulkesen,2 Arzu Kaya,2 Gul Ayden Kal,2 Dilara Kaman,3 Turkan Tuncer2 1Department of Rheumatology, Medicana International Samsun Hospital, Samsun, Turkey; 2Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Firat University, Faculty of Med...

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Autores principales:	Ulusoy H, Akgol G, Gulkesen A, Kaya A, Ayden Kal G, Kaman D, Tuncer T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Heat shock protein HSP rheumatoid arthritis ankylosing spondylitis Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/e1e5ced1897a46fab94dd96c01df0eb5
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spelling	oai:doaj.org-article:e1e5ced1897a46fab94dd96c01df0eb52021-12-02T06:09:29ZSerum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis1179-156Xhttps://doaj.org/article/e1e5ced1897a46fab94dd96c01df0eb52018-05-01T00:00:00Zhttps://www.dovepress.com/serum-heat-shock-protein-65-antibody-levels-are-elevated-but-not-assoc-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XHasan Ulusoy,1 Gurkan Akgol,2 Arif Gulkesen,2 Arzu Kaya,2 Gul Ayden Kal,2 Dilara Kaman,3 Turkan Tuncer2 1Department of Rheumatology, Medicana International Samsun Hospital, Samsun, Turkey; 2Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Firat University, Faculty of Medicine, Elazig, Turkey; 3Department of Biochemistry, Firat University, Faculty of Medicine, Elazig, Turkey Objectives: Heat-shock proteins (HSPs) have gained increased interest for their role in autoimmune disorders. These proteins are targeted by the immune system in various autoimmune diseases. The aim of this study was to assess the serum heat-shock protein-65 antibody (anti-HSP65) levels and their clinical significance in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Patients and methods: A total of 30 patients with RA, 30 patients with AS, and 30 healthy controls were enrolled in this study. All patients were assessed using routine clinical and laboratory evaluations. Serum anti-HSP65 levels were determined by ELISA. Results: Serum anti-HSP65 levels of both RA and AS patients were significantly higher than those of controls (p=0.014 and p=0.001, respectively). No association was found between serum anti-HSP65 levels and disease activity in either RA or AS patients. There was a significant correlation between anti-HSP65 and anti-cyclic citrullinated peptide levels in patients with RA (p=0.024). Conclusion: In this study, serum anti-HSP65 levels were increased, but not associated with disease activity in both RA and AS patients. These results suggest that HSP antigens may play a role in the pathogenesis. However, further follow-up studies are needed. Identification of target antigens such as HSP65 is vital to developing new immunotherapeutic agents. Keywords: heat-shock protein, HSP, rheumatoid arthritis, ankylosing spondylitisUlusoy HAkgol GGulkesen AKaya AAyden Kal GKaman DTuncer TDove Medical PressarticleHeat shock proteinHSPrheumatoid arthritisankylosing spondylitisDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 10, Pp 55-60 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Heat shock protein HSP rheumatoid arthritis ankylosing spondylitis Diseases of the musculoskeletal system RC925-935
spellingShingle	Heat shock protein HSP rheumatoid arthritis ankylosing spondylitis Diseases of the musculoskeletal system RC925-935 Ulusoy H Akgol G Gulkesen A Kaya A Ayden Kal G Kaman D Tuncer T Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis
description	Hasan Ulusoy,1 Gurkan Akgol,2 Arif Gulkesen,2 Arzu Kaya,2 Gul Ayden Kal,2 Dilara Kaman,3 Turkan Tuncer2 1Department of Rheumatology, Medicana International Samsun Hospital, Samsun, Turkey; 2Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Firat University, Faculty of Medicine, Elazig, Turkey; 3Department of Biochemistry, Firat University, Faculty of Medicine, Elazig, Turkey Objectives: Heat-shock proteins (HSPs) have gained increased interest for their role in autoimmune disorders. These proteins are targeted by the immune system in various autoimmune diseases. The aim of this study was to assess the serum heat-shock protein-65 antibody (anti-HSP65) levels and their clinical significance in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Patients and methods: A total of 30 patients with RA, 30 patients with AS, and 30 healthy controls were enrolled in this study. All patients were assessed using routine clinical and laboratory evaluations. Serum anti-HSP65 levels were determined by ELISA. Results: Serum anti-HSP65 levels of both RA and AS patients were significantly higher than those of controls (p=0.014 and p=0.001, respectively). No association was found between serum anti-HSP65 levels and disease activity in either RA or AS patients. There was a significant correlation between anti-HSP65 and anti-cyclic citrullinated peptide levels in patients with RA (p=0.024). Conclusion: In this study, serum anti-HSP65 levels were increased, but not associated with disease activity in both RA and AS patients. These results suggest that HSP antigens may play a role in the pathogenesis. However, further follow-up studies are needed. Identification of target antigens such as HSP65 is vital to developing new immunotherapeutic agents. Keywords: heat-shock protein, HSP, rheumatoid arthritis, ankylosing spondylitis
format	article
author	Ulusoy H Akgol G Gulkesen A Kaya A Ayden Kal G Kaman D Tuncer T
author_facet	Ulusoy H Akgol G Gulkesen A Kaya A Ayden Kal G Kaman D Tuncer T
author_sort	Ulusoy H
title	Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis
title_short	Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis
title_full	Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis
title_fullStr	Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis
title_full_unstemmed	Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis
title_sort	serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/e1e5ced1897a46fab94dd96c01df0eb5
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Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis

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