A Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Noninvasive Music-Induced Opening of the Blood–Brain Barrier with EEG Markers

The lymphatic system of the brain meninges and head plays a crucial role in the clearance of amyloid-β protein (Aβ), a peptide thought to be pathogenic in Alzheimer’s disease (AD), from the brain. The development of methods to modulate lymphatic clearance of Aβ from the brain coild be a revolutionar...

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Autores principales:	Oxana Semyachkina-Glushkovskaya, Alexander Khorovodov, Ivan Fedosov, Alexey Pavlov, Alexander Shirokov, Ali Esmat Sharif, Alexander Dubrovsky, Inna Blokhina, Andrey Terskov, Nikita Navolokin, Arina Evsukova, Georgy Karandin, Dariya Elovenko, Maria Tzoy, Vasily Ageev, Ilana Agranovich, Valeria Telnova, Anna Tsven, Elena Saranceva, Tatyana Iskra, Jürgen Kurths
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	music blood–brain barrier lymphatic system amyloid-β protein detrended fluctuation analysis electroencephalographic patterns Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e1ead22a95774fd7809d7e68d9f5eeea
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spelling	oai:doaj.org-article:e1ead22a95774fd7809d7e68d9f5eeea2021-11-11T15:19:35ZA Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Noninvasive Music-Induced Opening of the Blood–Brain Barrier with EEG Markers10.3390/app1121102872076-3417https://doaj.org/article/e1ead22a95774fd7809d7e68d9f5eeea2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/10287https://doaj.org/toc/2076-3417The lymphatic system of the brain meninges and head plays a crucial role in the clearance of amyloid-β protein (Aβ), a peptide thought to be pathogenic in Alzheimer’s disease (AD), from the brain. The development of methods to modulate lymphatic clearance of Aβ from the brain coild be a revolutionary step in the therapy of AD. The opening of the blood–brain barrier (OBBB) by focused ultrasound is considered as a possible tool for stimulation of clearance of Aβ from the brain of humans and animals. Here, we propose an alternative method of noninvasive music-induced OBBB that is accompanied by the activation of clearance of fluorescent Aβ (Fαβ) from the mouse brain. Using confocal imaging, fluorescence microscopy, and magnetic resonance tomography, we clearly demonstrate that OBBB by music stimulates the movement of Fαβ and Omniscan in the cerebrospinal fluid and lymphatic clearance of Fαβ from the brain. We propose the extended detrended fluctuation analysis (EDFA) as a promising method for the identification of OBBB markers in the electroencephalographic (EEG) patterns. These pilot results suggest that music-induced OBBB and the EDFA analysis of EEG can be a noninvasive, low-cost, labeling-free, clinical perspective and completely new approach for the treatment and monitoring of AD.Oxana Semyachkina-GlushkovskayaAlexander KhorovodovIvan FedosovAlexey PavlovAlexander ShirokovAli Esmat SharifAlexander DubrovskyInna BlokhinaAndrey TerskovNikita NavolokinArina EvsukovaGeorgy KarandinDariya ElovenkoMaria TzoyVasily AgeevIlana AgranovichValeria TelnovaAnna TsvenElena SarancevaTatyana IskraJürgen KurthsMDPI AGarticlemusicblood–brain barrierlymphatic systemamyloid-β proteindetrended fluctuation analysiselectroencephalographic patternsTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10287, p 10287 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	music blood–brain barrier lymphatic system amyloid-β protein detrended fluctuation analysis electroencephalographic patterns Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	music blood–brain barrier lymphatic system amyloid-β protein detrended fluctuation analysis electroencephalographic patterns Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Oxana Semyachkina-Glushkovskaya Alexander Khorovodov Ivan Fedosov Alexey Pavlov Alexander Shirokov Ali Esmat Sharif Alexander Dubrovsky Inna Blokhina Andrey Terskov Nikita Navolokin Arina Evsukova Georgy Karandin Dariya Elovenko Maria Tzoy Vasily Ageev Ilana Agranovich Valeria Telnova Anna Tsven Elena Saranceva Tatyana Iskra Jürgen Kurths A Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Noninvasive Music-Induced Opening of the Blood–Brain Barrier with EEG Markers
description	The lymphatic system of the brain meninges and head plays a crucial role in the clearance of amyloid-β protein (Aβ), a peptide thought to be pathogenic in Alzheimer’s disease (AD), from the brain. The development of methods to modulate lymphatic clearance of Aβ from the brain coild be a revolutionary step in the therapy of AD. The opening of the blood–brain barrier (OBBB) by focused ultrasound is considered as a possible tool for stimulation of clearance of Aβ from the brain of humans and animals. Here, we propose an alternative method of noninvasive music-induced OBBB that is accompanied by the activation of clearance of fluorescent Aβ (Fαβ) from the mouse brain. Using confocal imaging, fluorescence microscopy, and magnetic resonance tomography, we clearly demonstrate that OBBB by music stimulates the movement of Fαβ and Omniscan in the cerebrospinal fluid and lymphatic clearance of Fαβ from the brain. We propose the extended detrended fluctuation analysis (EDFA) as a promising method for the identification of OBBB markers in the electroencephalographic (EEG) patterns. These pilot results suggest that music-induced OBBB and the EDFA analysis of EEG can be a noninvasive, low-cost, labeling-free, clinical perspective and completely new approach for the treatment and monitoring of AD.
format	article
author	Oxana Semyachkina-Glushkovskaya Alexander Khorovodov Ivan Fedosov Alexey Pavlov Alexander Shirokov Ali Esmat Sharif Alexander Dubrovsky Inna Blokhina Andrey Terskov Nikita Navolokin Arina Evsukova Georgy Karandin Dariya Elovenko Maria Tzoy Vasily Ageev Ilana Agranovich Valeria Telnova Anna Tsven Elena Saranceva Tatyana Iskra Jürgen Kurths
author_facet	Oxana Semyachkina-Glushkovskaya Alexander Khorovodov Ivan Fedosov Alexey Pavlov Alexander Shirokov Ali Esmat Sharif Alexander Dubrovsky Inna Blokhina Andrey Terskov Nikita Navolokin Arina Evsukova Georgy Karandin Dariya Elovenko Maria Tzoy Vasily Ageev Ilana Agranovich Valeria Telnova Anna Tsven Elena Saranceva Tatyana Iskra Jürgen Kurths
author_sort	Oxana Semyachkina-Glushkovskaya
title	A Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Noninvasive Music-Induced Opening of the Blood–Brain Barrier with EEG Markers
title_short	A Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Noninvasive Music-Induced Opening of the Blood–Brain Barrier with EEG Markers
title_full	A Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Noninvasive Music-Induced Opening of the Blood–Brain Barrier with EEG Markers
title_fullStr	A Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Noninvasive Music-Induced Opening of the Blood–Brain Barrier with EEG Markers
title_full_unstemmed	A Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Noninvasive Music-Induced Opening of the Blood–Brain Barrier with EEG Markers
title_sort	novel method to stimulate lymphatic clearance of beta-amyloid from mouse brain using noninvasive music-induced opening of the blood–brain barrier with eeg markers
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e1ead22a95774fd7809d7e68d9f5eeea
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A Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Noninvasive Music-Induced Opening of the Blood–Brain Barrier with EEG Markers

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