Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90

Cachexia affects many cancer patients causing weight loss and increasing mortality. Here, the authors identify extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor cells, to be responsible for tumor induction of cachexia.

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Autores principales:	Guohua Zhang, Zhelong Liu, Hui Ding, Yong Zhou, Hoang Anh Doan, Ka Wai Thomas Sin, Zhiren J. Zhu, Rene Flores, Yefei Wen, Xing Gong, Qingyun Liu, Yi-Ping Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e1eba5b33bfe496a995e5d12f008fd11
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spelling	oai:doaj.org-article:e1eba5b33bfe496a995e5d12f008fd112021-12-02T17:06:04ZTumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp9010.1038/s41467-017-00726-x2041-1723https://doaj.org/article/e1eba5b33bfe496a995e5d12f008fd112017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00726-xhttps://doaj.org/toc/2041-1723Cachexia affects many cancer patients causing weight loss and increasing mortality. Here, the authors identify extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor cells, to be responsible for tumor induction of cachexia.Guohua ZhangZhelong LiuHui DingYong ZhouHoang Anh DoanKa Wai Thomas SinZhiren J. ZhuRene FloresYefei WenXing GongQingyun LiuYi-Ping LiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guohua Zhang Zhelong Liu Hui Ding Yong Zhou Hoang Anh Doan Ka Wai Thomas Sin Zhiren J. Zhu Rene Flores Yefei Wen Xing Gong Qingyun Liu Yi-Ping Li Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
description	Cachexia affects many cancer patients causing weight loss and increasing mortality. Here, the authors identify extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor cells, to be responsible for tumor induction of cachexia.
format	article
author	Guohua Zhang Zhelong Liu Hui Ding Yong Zhou Hoang Anh Doan Ka Wai Thomas Sin Zhiren J. Zhu Rene Flores Yefei Wen Xing Gong Qingyun Liu Yi-Ping Li
author_facet	Guohua Zhang Zhelong Liu Hui Ding Yong Zhou Hoang Anh Doan Ka Wai Thomas Sin Zhiren J. Zhu Rene Flores Yefei Wen Xing Gong Qingyun Liu Yi-Ping Li
author_sort	Guohua Zhang
title	Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
title_short	Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
title_full	Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
title_fullStr	Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
title_full_unstemmed	Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
title_sort	tumor induces muscle wasting in mice through releasing extracellular hsp70 and hsp90
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e1eba5b33bfe496a995e5d12f008fd11
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Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90

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