Evolution under fluctuating environments explains observed robustness in metabolic networks.

A high level of robustness against gene deletion is observed in many organisms. However, it is still not clear which biochemical features underline this robustness and how these are acquired during evolution. One hypothesis, specific to metabolic networks, is that robustness emerges as a byproduct o...

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Auteurs principaux:	Orkun S Soyer, Thomas Pfeiffer
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2010
Sujets:	Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/e1ed85b58d804358891f5a46a03af64f
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spelling	oai:doaj.org-article:e1ed85b58d804358891f5a46a03af64f2021-11-18T05:49:21ZEvolution under fluctuating environments explains observed robustness in metabolic networks.1553-734X1553-735810.1371/journal.pcbi.1000907https://doaj.org/article/e1ed85b58d804358891f5a46a03af64f2010-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20865149/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358A high level of robustness against gene deletion is observed in many organisms. However, it is still not clear which biochemical features underline this robustness and how these are acquired during evolution. One hypothesis, specific to metabolic networks, is that robustness emerges as a byproduct of selection for biomass production in different environments. To test this hypothesis we performed evolutionary simulations of metabolic networks under stable and fluctuating environments. We find that networks evolved under the latter scenario can better tolerate single gene deletion in specific environments. Such robustness is underlined by an increased number of independent fluxes and multifunctional enzymes in the evolved networks. Observed robustness in networks evolved under fluctuating environments was "apparent," in the sense that it decreased significantly as we tested effects of gene deletions under all environments experienced during evolution. Furthermore, when we continued evolution of these networks under a stable environment, we found that any robustness they had acquired was completely lost. These findings provide evidence that evolution under fluctuating environments can account for the observed robustness in metabolic networks. Further, they suggest that organisms living under stable environments should display lower robustness in their metabolic networks, and that robustness should decrease upon switching to more stable environments.Orkun S SoyerThomas PfeifferPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 6, Iss 8 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Orkun S Soyer Thomas Pfeiffer Evolution under fluctuating environments explains observed robustness in metabolic networks.
description	A high level of robustness against gene deletion is observed in many organisms. However, it is still not clear which biochemical features underline this robustness and how these are acquired during evolution. One hypothesis, specific to metabolic networks, is that robustness emerges as a byproduct of selection for biomass production in different environments. To test this hypothesis we performed evolutionary simulations of metabolic networks under stable and fluctuating environments. We find that networks evolved under the latter scenario can better tolerate single gene deletion in specific environments. Such robustness is underlined by an increased number of independent fluxes and multifunctional enzymes in the evolved networks. Observed robustness in networks evolved under fluctuating environments was "apparent," in the sense that it decreased significantly as we tested effects of gene deletions under all environments experienced during evolution. Furthermore, when we continued evolution of these networks under a stable environment, we found that any robustness they had acquired was completely lost. These findings provide evidence that evolution under fluctuating environments can account for the observed robustness in metabolic networks. Further, they suggest that organisms living under stable environments should display lower robustness in their metabolic networks, and that robustness should decrease upon switching to more stable environments.
format	article
author	Orkun S Soyer Thomas Pfeiffer
author_facet	Orkun S Soyer Thomas Pfeiffer
author_sort	Orkun S Soyer
title	Evolution under fluctuating environments explains observed robustness in metabolic networks.
title_short	Evolution under fluctuating environments explains observed robustness in metabolic networks.
title_full	Evolution under fluctuating environments explains observed robustness in metabolic networks.
title_fullStr	Evolution under fluctuating environments explains observed robustness in metabolic networks.
title_full_unstemmed	Evolution under fluctuating environments explains observed robustness in metabolic networks.
title_sort	evolution under fluctuating environments explains observed robustness in metabolic networks.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/e1ed85b58d804358891f5a46a03af64f
work_keys_str_mv	AT orkunssoyer evolutionunderfluctuatingenvironmentsexplainsobservedrobustnessinmetabolicnetworks AT thomaspfeiffer evolutionunderfluctuatingenvironmentsexplainsobservedrobustnessinmetabolicnetworks
_version_	1718424823077535744

Evolution under fluctuating environments explains observed robustness in metabolic networks.

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