Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids

Medical research in the recent years has achieved significant progress due to the increasing prominence of organoid technology. Various developed tissue organoids bridge the limitations of conventional 2D cell culture and animal models by recapitulating in vivo cellular complexity. Current 3D cardia...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jeremy Kah Sheng Pang, Beatrice Xuan Ho, Woon-Khiong Chan, Boon-Seng Soh
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	stem cell embryonic development organoid systems cardiovascular disease modelling drug screening biomaterials Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e1efb5545d6b48ccb3b29587391405fb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e1efb5545d6b48ccb3b29587391405fb
record_format	dspace
spelling	oai:doaj.org-article:e1efb5545d6b48ccb3b29587391405fb2021-12-02T11:12:15ZInsights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids2296-634X10.3389/fcell.2021.788955https://doaj.org/article/e1efb5545d6b48ccb3b29587391405fb2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.788955/fullhttps://doaj.org/toc/2296-634XMedical research in the recent years has achieved significant progress due to the increasing prominence of organoid technology. Various developed tissue organoids bridge the limitations of conventional 2D cell culture and animal models by recapitulating in vivo cellular complexity. Current 3D cardiac organoid cultures have shown their utility in modelling key developmental hallmarks of heart organogenesis, but the complexity of the organ demands a more versatile model that can investigate more fundamental parameters, such as structure, organization and compartmentalization of a functioning heart. This review will cover the prominence of cardiac organoids in recent research, unpack current in vitro 3D models of the developing heart and look into the prospect of developing physiologically appropriate cardiac organoids with translational applicability. In addition, we discuss some of the limitations of existing cardiac organoid models in modelling embryonic development of the heart and manifestation of cardiac diseases.Jeremy Kah Sheng PangJeremy Kah Sheng PangBeatrice Xuan HoBeatrice Xuan HoWoon-Khiong ChanBoon-Seng SohBoon-Seng SohFrontiers Media S.A.articlestem cellembryonic developmentorganoid systemscardiovascular disease modellingdrug screeningbiomaterialsBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stem cell embryonic development organoid systems cardiovascular disease modelling drug screening biomaterials Biology (General) QH301-705.5
spellingShingle	stem cell embryonic development organoid systems cardiovascular disease modelling drug screening biomaterials Biology (General) QH301-705.5 Jeremy Kah Sheng Pang Jeremy Kah Sheng Pang Beatrice Xuan Ho Beatrice Xuan Ho Woon-Khiong Chan Boon-Seng Soh Boon-Seng Soh Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids
description	Medical research in the recent years has achieved significant progress due to the increasing prominence of organoid technology. Various developed tissue organoids bridge the limitations of conventional 2D cell culture and animal models by recapitulating in vivo cellular complexity. Current 3D cardiac organoid cultures have shown their utility in modelling key developmental hallmarks of heart organogenesis, but the complexity of the organ demands a more versatile model that can investigate more fundamental parameters, such as structure, organization and compartmentalization of a functioning heart. This review will cover the prominence of cardiac organoids in recent research, unpack current in vitro 3D models of the developing heart and look into the prospect of developing physiologically appropriate cardiac organoids with translational applicability. In addition, we discuss some of the limitations of existing cardiac organoid models in modelling embryonic development of the heart and manifestation of cardiac diseases.
format	article
author	Jeremy Kah Sheng Pang Jeremy Kah Sheng Pang Beatrice Xuan Ho Beatrice Xuan Ho Woon-Khiong Chan Boon-Seng Soh Boon-Seng Soh
author_facet	Jeremy Kah Sheng Pang Jeremy Kah Sheng Pang Beatrice Xuan Ho Beatrice Xuan Ho Woon-Khiong Chan Boon-Seng Soh Boon-Seng Soh
author_sort	Jeremy Kah Sheng Pang
title	Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids
title_short	Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids
title_full	Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids
title_fullStr	Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids
title_full_unstemmed	Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids
title_sort	insights to heart development and cardiac disease models using pluripotent stem cell derived 3d organoids
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e1efb5545d6b48ccb3b29587391405fb
work_keys_str_mv	AT jeremykahshengpang insightstoheartdevelopmentandcardiacdiseasemodelsusingpluripotentstemcellderived3dorganoids AT jeremykahshengpang insightstoheartdevelopmentandcardiacdiseasemodelsusingpluripotentstemcellderived3dorganoids AT beatricexuanho insightstoheartdevelopmentandcardiacdiseasemodelsusingpluripotentstemcellderived3dorganoids AT beatricexuanho insightstoheartdevelopmentandcardiacdiseasemodelsusingpluripotentstemcellderived3dorganoids AT woonkhiongchan insightstoheartdevelopmentandcardiacdiseasemodelsusingpluripotentstemcellderived3dorganoids AT boonsengsoh insightstoheartdevelopmentandcardiacdiseasemodelsusingpluripotentstemcellderived3dorganoids AT boonsengsoh insightstoheartdevelopmentandcardiacdiseasemodelsusingpluripotentstemcellderived3dorganoids
_version_	1718396200943616000

Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids

Ejemplares similares